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Beclabuvir

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Purity:99.93%

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COA LCMS

Beclabuvir

Catalog No. T10493Cas No. 958002-33-0

Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase, inhibiting recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).

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Pack Size	Price	Availability	Quantity
1 mg	$137	In Stock

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Product Introduction

Bioactivity

Description	Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase, inhibiting recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).
Targets&IC50	NS5B protein:< 28 nM
In vitro	2- or 3-drug combinations of beraprevir with pegIFN/RBV and with a range of DAAs (e.g., HCV NS5A inhibitors, NS3 protease inhibitors, and/or nucleoside analog NS5B inhibitors) can show additive or synergistic antiviral activity [2].
In vivo	The combination of Beclabuvir with daclatasvir and asunaprevir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1, which is the most common genotype worldwide [1].
Alias	BMS-791325

Chemical Properties

Molecular Weight	659.84
Formula	C36H45N5O5S
Cas No.	958002-33-0

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 20 mg/mL (30.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5155 mL	7.5776 mL	15.1552 mL	75.7759 mL
5 mM	0.3031 mL	1.5155 mL	3.0310 mL	15.1552 mL
10 mM	0.1516 mL	0.7578 mL	1.5155 mL	7.5776 mL
20 mM	0.0758 mL	0.3789 mL	0.7578 mL	3.7888 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc