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BI 99179
🥰Excellent
Catalog No. T14570Cas No. 1291779-76-4
Alias BI99179
BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.
BI 99179
🥰Excellent
Catalog No. T14570Alias BI99179Cas No. 1291779-76-4
BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 5 mg | $72 | In Stock | |
| 10 mg | $108 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $82 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BI 99179 is a selective and potent inhibitor of type I fatty acid synthase (FAS), a tool compound for targeting FAS for cancer research. |
| Targets&IC50 | N-42 cells:0.6 μM, Fas:79 nM |
| In vitro | BI 99179 demonstrated significant efficacy in mouse hypothalamic N-42 cells with an IC50 of 0.6 μM and no significant LDH release below 30 μM in cytotoxicity assays. [1] BI 99179 showed antiproliferative effects in human glioma GAMG cells at concentrations of 1, 2 and 4 μM. [2] |
| In vivo | Pharmacokinetically, BI 99179 also performed very well in male Han/Wistar rats, with a half-life (t1/2) of 3.0 hours at an oral dose of 4 mg/kg. [1] |
| Alias | BI99179 |
| Molecular Weight | 391.46 |
| Formula | C23H25N3O3 |
| Cas No. | 1291779-76-4 |
| Smiles | N(C(=O)[C@H]1C[C@@H](NC(CC)=O)CC1)(C)C2=CC=C(C3=NC=4C(O3)=CC=CC4)C=C2 |
| Relative Density. | 1.25 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (255.45 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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