TVB-3664

TVB-3664 significantly decreases tubulin palmitoylation and mRNA expression. TVB-3664 is a reversible and highly bioavailable fatty acid synthase inhibitor (IC50: 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively).

Catalog No. T17181Cas No. 2097262-58-1

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Purity:99.28%

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COA HPLC HNMR

TVB-3664

Catalog No. T17181Cas No. 2097262-58-1

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Pack Size	Price	Availability
1 mg	$123	In Stock
5 mg	$297	In Stock
10 mg	$479	In Stock
25 mg	$787	In Stock
50 mg	$1,160	In Stock
100 mg	$1,580	In Stock
1 mL x 10 mM (in DMSO)	$327	In Stock

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Product Introduction

Bioactivity

Description	TVB-3664 significantly decreases tubulin palmitoylation and mRNA expression. TVB-3664 is a reversible and highly bioavailable fatty acid synthase inhibitor (IC50: 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively).
Targets&IC50	FASN:18 nM
In vitro	TVB-3664 reduces viability in multiple tumor cell lines from solid and hematopoietic tumor types. TVB-3664 (0-1 μM, 7 days) displays anti-tumor activity in CaCo2, HT29, and LIM2405 cell lines [1].
In vivo	In Pt 2614, Pt 2449PT, and Pt 2402 PDX models, TVB-3664 (3 mg/kg or 6 mg/kg, oral gavage, daily, 4 weeks) treatment leads to a significant reduction in tumor volume and tumor weight, with an average reduction in tumor weight of 30%, 37.5%, and 51.5%, respectively [1].

Chemical Properties

Molecular Weight	468.47
Formula	C₂₅H₂₃F₃N₄O₂
Cas No.	2097262-58-1

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (106.73 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1346 mL	10.6730 mL	21.3461 mL	106.7304 mL
5 mM	0.4269 mL	2.1346 mL	4.2692 mL	21.3461 mL
10 mM	0.2135 mL	1.0673 mL	2.1346 mL	10.6730 mL
20 mM	0.1067 mL	0.5337 mL	1.0673 mL	5.3365 mL
50 mM	0.0427 mL	0.2135 mL	0.4269 mL	2.1346 mL
100 mM	0.0213 mL	0.1067 mL	0.2135 mL	1.0673 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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