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Denifanstat

Denifanstat (FASN-IN-2) is a fatty acid synthase (FASN) inhibitor (IC50=0.052 μM, EC50=0.072 μM) with selective and oral activity. Denifanstat has been used in studies of steatohepatitis.

Catalog No. T15271Cas No. 1399177-37-7

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Purity:99.44%

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COA HPLC HNMR

Denifanstat

Catalog No. T15271Cas No. 1399177-37-7

Denifanstat (FASN-IN-2) is a fatty acid synthase (FASN) inhibitor (IC50=0.052 μM, EC50=0.072 μM) with selective and oral activity. Denifanstat has been used in studies of steatohepatitis.

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Pack Size	Price	Availability
1 mg	$83	In Stock
5 mg	$197	In Stock
10 mg	$332	In Stock
25 mg	$558	In Stock
50 mg	$788	In Stock
100 mg	$1,120	In Stock
500 mg	$2,230	In Stock
1 mL x 10 mM (in DMSO)	$228	In Stock

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Product Introduction

Bioactivity

Description	Denifanstat (FASN-IN-2) is a fatty acid synthase (FASN) inhibitor (IC50=0.052 μM, EC50=0.072 μM) with selective and oral activity. Denifanstat has been used in studies of steatohepatitis.
Targets&IC50	FASN:0.052 μM
In vitro	METHODS: MDA-MD-231 and MDA-MB-231-BR cells were treated with Denifanstat (1-10.3 µM) for 6-30 h. Cell migration was detected by wound healing assay. RESULTS: Cell migration was inhibited in MDA-MB-231-BR cells but not in parental MDA-MD-231 cells in a dose-dependent manner. [1]
In vivo	METHODS: To assay antitumor activity in vivo, Denifanstat (100 mg/kg, 30% PEG400) was administered by gavage to SCID mice bearing PC-3M/HOXB13KD xenografts once daily for six weeks. RESULTS: Five weeks after inoculation, HOXB13-KD mice showed significant metastasis in IVIS, which was completely alleviated by Denifanstat treatment.Denifanstat treatment significantly prolonged metastasis-free survival in both control and HOXB13-KD mice. [2]
Alias	FASN-IN-2, TVB2640, TVB-2640

Chemical Properties

Molecular Weight	439.55
Formula	C₂₇H₂₉N₅O
Cas No.	1399177-37-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 60 mg/mL (136.5 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2751 mL	11.3753 mL	22.7505 mL	113.7527 mL
5 mM	0.4550 mL	2.2751 mL	4.5501 mL	22.7505 mL
10 mM	0.2275 mL	1.1375 mL	2.2751 mL	11.3753 mL
20 mM	0.1138 mL	0.5688 mL	1.1375 mL	5.6876 mL
50 mM	0.0455 mL	0.2275 mL	0.4550 mL	2.2751 mL
100 mM	0.0228 mL	0.1138 mL	0.2275 mL	1.1375 mL

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