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BML-286
🥰Excellent
Catalog No. T200419Cas No. 294891-81-9
Alias BML286
BML-286 is a WNT pathway modulator with potential anticancer activity, inducing β-catenin- and TCF-dependent transcriptional activity, and can be used in the study of degenerative diseases, intestinal, breast, bladder, gastric, melanoma, leukemia, hepatocellular carcinoma and nephroblastoma.
BML-286
🥰Excellent
Catalog No. T200419Alias BML286Cas No. 294891-81-9
BML-286 is a WNT pathway modulator with potential anticancer activity, inducing β-catenin- and TCF-dependent transcriptional activity, and can be used in the study of degenerative diseases, intestinal, breast, bladder, gastric, melanoma, leukemia, hepatocellular carcinoma and nephroblastoma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $93 | In Stock | |
| 5 mg | $233 | In Stock | |
| 10 mg | $350 | In Stock | |
| 25 mg | $595 | In Stock | |
| 50 mg | $893 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BML-286 is a WNT pathway modulator with potential anticancer activity, inducing β-catenin- and TCF-dependent transcriptional activity, and can be used in the study of degenerative diseases, intestinal, breast, bladder, gastric, melanoma, leukemia, hepatocellular carcinoma and nephroblastoma. |
| Targets&IC50 | Wnt pathway-dependent PC3 cells:12.5 μM, PDZ structural domain of Dishevelled protein:10.6 μM (Kd) |
| In vitro | BML-286 (Compound 3289-8625) inhibits the Wnt signaling pathway by binding to the PDZ structural domain of Dishevelled (Dvl) protein (Kd = 10.6 μM). In addition, BML-286 blocked Wnt3a-induced transcriptional activity and effectively inhibited the growth of Wnt pathway-dependent prostate cancer PC-3 cells in vitro (IC50 = 12.5 μM). [1] |
| Alias | BML286 |
| Molecular Weight | 374.39 |
| Formula | C22H18N2O4 |
| Cas No. | 294891-81-9 |
| Smiles | O=C(O)C=1C=CC=CC1NC(=O)C=2C=CC=C(C2)NC(=O)CC=3C=CC=CC3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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