Shopping Cart
- Remove All
Your shopping cart is currently empty
bpV(phen)
😃Good
Catalog No. T10594Cas No. 42494-73-5
bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).
bpV(phen)
😃Good
Catalog No. T10594Cas No. 42494-73-5
bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "bpV(phen)"
Ginkgolic acid C17:1
T6S2116111047-30-4
1. Ginkgolic acid C17:1 can significantly inhibit enterohemorrhagic Escherichia coli O157:H7(EHEC) biofilm formation on the surfaces of polystyrene and glass, and on nylon membranes.
- $92
Size
QTY
VO-Ohpic trihydrate
T7012476310-60-8
VO-Ohpic trihydrate (VO-Ohpic) is a potent inhibitor of PTEN (phosphatase and tensin homolog) with IC50 of 35 nM.
- $52
Size
QTY
Cucurbitacin B
Cited
DATISCACIN, Cuc B, Amarine
T34046199-67-3
Cucurbitacin B (Cuc B) has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
- $44
Size
QTY
CitedBpV(HOpic)
bpV (HOpic)
T7953722494-26-0
BpV(HOpic) (bpV (HOpic)) is a potent inhibitor of PTEN (IC50 of 14 nM).
- $59
Size
QTY
Afzelin
Kaempferol-3-O-rhamnoside
TN1362482-39-3
Afzelin (Kaempferol-3-O-rhamnoside) exhibits several cellular activities such as DNA-protective, antibacterial, antioxidant, anti-inflammatory, and UV-absorbing properties, potentially protecting human skin from UVB-induced damage through a combination of UV-absorbing and cellular actions. Afzelin mitigates mitochondrial damage, promotes mitochondrial biogenesis, and reduces levels of mitophagy-related proteins, parkin and PTEN-induced putative kinase 1.
- $41
Size
QTY
Oroxin B Cited
Hypocretin-2
T3780114482-86-9
Oroxin B (Hypocretin-2) has antioxidant activity.
- $110
Size
QTY
CitedSF1670 Cited
PTPase CD45 Inhibitor, PTP CD45 Inhibitor
T6667345630-40-2
SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.
- $37
Size
QTY
CitedValinomycin Cited
NSC 122023
TP10722001-95-8
Valinomycin (NSC-122023) is a cyclic depsipeptide antibiotic and a potassium-specific ionophore.Valinomycin induces PINK1 activation and promotes Parkin phosphorylation at Ser65.
- $89
Size
QTY
CitedMTK458
Mitophagy activator 1, EP-0035985
T724202499962-58-0
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.
- $32
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN). |
| Targets&IC50 | PTEN:38 nM , PTP-β:343 nM , PTP1B:920 nM |
| In vitro | bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment further decreases cell viability and increases apoptosis in H/R-injured H9c2 cells, significantly promotes cytoplasmic Cytochrome C accumulation, and inhibits PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy in H/R-injured H9c2 cells [1]. |
| In vivo | The treatment with bpV(phen) (5 mg/kg; i.p.; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) results in a significant reduction in average tumor volume [1]. |
| Molecular Weight | 350.24 |
| Formula | C12H8KN2O5V |
| Cas No. | 42494-73-5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy bpV(phen) | purchase bpV(phen) | bpV(phen) cost | order bpV(phen) | bpV(phen) chemical structure | bpV(phen) in vivo | bpV(phen) in vitro | bpV(phen) formula | bpV(phen) molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.