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MTK458

🥰Excellent
Catalog No. T72420Cas No. 2499962-58-0
Alias Mitophagy activator 1, EP-0035985

MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.

MTK458

MTK458

🥰Excellent
Purity: 98.36%
Catalog No. T72420Alias Mitophagy activator 1, EP-0035985Cas No. 2499962-58-0
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.
Pack SizePriceAvailabilityQuantity
1 mg$32In Stock
5 mg$73In Stock
10 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$80In Stock
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Purity:98.36%
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Product Introduction

Bioactivity
Description
MTK458 (EP-0035985) is an orally active and brain-permeable PINK1 activator that promotes pathological clearance of alpha-synuclein and reduces pUb in a PFF inoculation model.MTK458 induces pathological alpha-synuclein clearance by stimulating dimerization and stabilization of the PINK1/TOM complex.MTK458 may be used in Parkinson's disease research.
In vitro
Mitophagy activator 1 (0.1-25 µM), as a brain-penetrant small molecule, binds to PINK1 and stabilizes the active heterocomplex, thereby enhancing mitochondrial autophagy. It clears pS129 α-synuclein aggregates in a dose-dependent manner at DIV9 and DIV12[1].
In vivo
In the striatum of mice injected with α-synuclein preformed fibrils (PFFs), Mitophagy activator 1 (50 mg/kg; oral gavage (p.o.), daily, for 6 months) rescued activity deficits in freely moving PFF mice and reduced the levels of inflammatory markers (TREM2, IL-6, and CXCL1)[1].
AliasMitophagy activator 1, EP-0035985
Chemical Properties
Molecular Weight332.32
FormulaC17H15F3N4
Cas No.2499962-58-0
SmilesN(C1=C2C(NC(C(F)(F)F)=C2)=NC=N1)[C@H]3C=4C(CCC3)=CC=CC4
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (240.73 mM), Sonification is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0091 mL15.0457 mL30.0915 mL150.4574 mL
5 mM0.6018 mL3.0091 mL6.0183 mL30.0915 mL
10 mM0.3009 mL1.5046 mL3.0091 mL15.0457 mL
20 mM0.1505 mL0.7523 mL1.5046 mL7.5229 mL
50 mM0.0602 mL0.3009 mL0.6018 mL3.0091 mL
100 mM0.0301 mL0.1505 mL0.3009 mL1.5046 mL

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