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BRD4 degrader AT1
Catalog No. T5439Cas No. 2098836-45-2
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
BRD4 degrader AT1
Catalog No. T5439Cas No. 2098836-45-2
BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,100 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | BRD4 degrader AT1 is a highly selective Brd4 degrader based on PROTAC technology, with a Kd of 44 nM for Brd4BD2 in cells. |
| Targets&IC50 | BRD2 BD1:111 nM (Kd), BRD3 BD1:35 nM (Kd), BRD2 BD2:94 nM (Kd), BRD2 BD1 KEA:35 nM (Kd), BRD4 BD1:75 nM (Kd), BRD4 BD2:44 nM (Kd), BRD3 BD2:39 nM (Kd), BRD4 BD2QVK:38.8 nM (Kd) |
| In vitro | BRD4 degrader AT1 is a highly selective Brd4 degrader, exhibiting a Kd of 44 nM for Brd4BD2 in cells, and shows Kds of 38.8 nM for mutant Brd4BD2 (QVK), 111 ± 14 nM for Brd2BD1, 94 ± 9 nM for Brd2BD2, 35 ± 3 nM for Brd3BD1, 39 ± 8 nM for Brd3BD2, 75 ± 23 nM for Brd4BD1, and 35 ± 4 nM for mutant Brd2BD1 (KEA). At concentrations of 1-3 μM, BRD4 degrader AT1 induces significant Brd4-selective depletion while exhibiting minimal activity against Brd2 and Brd3[1]. |
| Molecular Weight | 972.68 |
| Formula | C48H58ClN9O5S3 |
| Cas No. | 2098836-45-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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