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BRD5631
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Catalog No. T10607Cas No. 2446154-91-0
BRD5631 is an autophagy enhancer that operates through an mTOR-independent pathway. It influences several cellular disease phenotypes associated with autophagy, such as protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production. BRD5631 can serve as a valuable tool for studying the role of autophagy in cellular homeostasis and disease. [1].
BRD5631
😃Good
Catalog No. T10607Cas No. 2446154-91-0
BRD5631 is an autophagy enhancer that operates through an mTOR-independent pathway. It influences several cellular disease phenotypes associated with autophagy, such as protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production. BRD5631 can serve as a valuable tool for studying the role of autophagy in cellular homeostasis and disease. [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | 2.033 € | 10-14 weeks | |
| 50 mg | 2.645 € | 10-14 weeks | |
| 100 mg | 3.344 € | 10-14 weeks |
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Product Introduction
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Chemical Properties
| Description | BRD5631 is an autophagy enhancer that operates through an mTOR-independent pathway. It influences several cellular disease phenotypes associated with autophagy, such as protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production. BRD5631 can serve as a valuable tool for studying the role of autophagy in cellular homeostasis and disease. [1]. |
| In vitro | BRD5631 treatment (10 μM, 48 hours) elevates LC3-II levels in HeLa cells, indicating an enhancement in autophagosome formation. This activity aligns with the observed increase in autolysosome numbers in the mCherry-GFP-LC3 assay [1], suggesting BRD5631 promotes autophagy not by directly inhibiting mTOR or its signaling pathway but through alternative mechanisms. Additionally, BRD5631 reduces IL-1β secretion via an autophagy-dependent process, underscoring its potential as a modulator of autophagy-related functions [1]. |
| Molecular Weight | 501.62 |
| Formula | C30H35N3O4 |
| Cas No. | 2446154-91-0 |
| Relative Density. | 1.21 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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