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Caloxin 2A1 TFA
🥰Excellent
Catalog No. T35923
Caloxin 2A1 TFA is a novel PM Ca2+ pump inhibitor. It inhibits human red blood cell Ca2+-Mg2+-ATPase, blocking Ca2+ dependent formation of a 140-kDa acid-stable acylphosphate.
Caloxin 2A1 TFA
🥰Excellent
Catalog No. T35923
Caloxin 2A1 TFA is a novel PM Ca2+ pump inhibitor. It inhibits human red blood cell Ca2+-Mg2+-ATPase, blocking Ca2+ dependent formation of a 140-kDa acid-stable acylphosphate.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $42 | In Stock | |
| 5 mg | $91 | In Stock | |
| 10 mg | $148 | In Stock | |
| 25 mg | $297 | In Stock | |
| 50 mg | $448 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Caloxin 2A1 TFA is a novel PM Ca2+ pump inhibitor. It inhibits human red blood cell Ca2+-Mg2+-ATPase, blocking Ca2+ dependent formation of a 140-kDa acid-stable acylphosphate. |
| In vitro | Caloxin 2A1 TFA showed inhibition of Ca²⁺-Mg²⁺-ATPase in human erythrocytes but had no significant effect on basal Mg²⁺-ATPase and Na²⁺-K⁺-ATPase activity in ghost cells and in the sarcoplasmic reticulum of skeletal muscle. In addition, Caloxin 2A1 TFA blocked the Ca²⁺-dependent generation of 140-kDa acid-stabilized acyl phosphate. [1] Caloxin 2A1 TFA promoted the apoptotic process in airway smooth muscle cells (ASMC). [2] |
| Molecular Weight | 1592.55 |
| Formula | C66H92F3N19O24 |
| Smiles | O=C(N1[C@@H](CCC1)C(N[C@@H](CO)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N[C@@H](CO)C(N[C@@H](CO)C(NCC(NCC(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@@H](NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@@H](N)C(C)C)=O)=O)=O)=O)=O)CC4=CNC5=CC=CC=C45.FC(F)(F)C(O)=O |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | H2O: 80.00 mg/mL (50.23 mM), Sonication is recommended.  DMSO: 80.00 mg/mL (50.23 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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