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CAY10784
🥰Excellent
Catalog No. T36035Cas No. 1245814-52-1
Alias STAT3-IN-17, CAY-10784, CAY 10784
CAY10784 (STAT3-IN-17) is a STAT3 inhibitor with antiproliferative and antitumor activities. CAY10784 showed antibacterial activity against Clostridium difficile.
CAY10784
🥰Excellent
Purity: 99.74%
Catalog No. T36035Alias STAT3-IN-17, CAY-10784, CAY 10784Cas No. 1245814-52-1
CAY10784 (STAT3-IN-17) is a STAT3 inhibitor with antiproliferative and antitumor activities. CAY10784 showed antibacterial activity against Clostridium difficile.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $59 | In Stock | |
| 5 mg | $213 | In Stock | |
| 10 mg | $372 | In Stock | |
| 25 mg | $787 | In Stock | |
| 50 mg | $1,260 | In Stock | |
| 100 mg | $1,980 | In Stock | |
| 200 mg | $2,730 | In Stock |
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Purity:99.74%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CAY10784 (STAT3-IN-17) is a STAT3 inhibitor with antiproliferative and antitumor activities. CAY10784 showed antibacterial activity against Clostridium difficile. |
| Targets&IC50 | HeLa cells:1.8 µM, A549 cells:3 µM, Caco2 cells:1.8 µM, HL-60 cells:1.2 µM, STAT3:0.74 µM, A375 cells:2.8 µM, U87MG cells:2.3 µM |
| In vitro | CAY10784 is a STAT3 inhibitor (IC50 = 0.74 µM) and a derivative of WP1066. [2] CAY10784 inhibits proliferation of HeLa (IC50s = 1.8 µM), Caco-2 (IC50s = 1.8 µM), A549 (IC50s = 3 µM), A375 (IC50s = 2.8 µM), U87MG (IC50s = 2.3 µM), and HL-60 (IC50s = 1.2 µM) cancer cells but not PC3 or HT-29 cancer cells (IC50s = >10 µM for both). CAY10784 is also active against H. pylori (MICs = 1.6 µM) and C. jejuni (MICs = 4.7 µM). [1] |
| Alias | STAT3-IN-17, CAY-10784, CAY 10784 |
| Molecular Weight | 317.24 |
| Formula | C11H6F3N3O3S |
| Cas No. | 1245814-52-1 |
| Smiles | O=C(C1=CC=C(C(F)(F)F)C=C1)NC2=NC=C([N+]([O-])=O)S2 |
Storage & Solubility Information
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMF:PBS (pH 7.2) (1:2): 0.33 mg/mL (1.04 mM), Sonication is recommended. H2O: < 1 mg/mL(insoluble or slightly soluble.) DMSO: 5 mg/mL(15.76 mM), Sonication is recommended. Ethanol: 1 mg/mL(3.15 mM), Sonication is recommended. DMF: 20 mg/mL(63.04 mM), Sonication is recommended. |
Solution Preparation Table | |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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