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CB-6644

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Purity:100%

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COA HNMR HPLC FNMR LCMS

CB-6644

Catalog No. T10693Cas No. 2316817-88-4

CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50 = 15 nM).

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Pack Size	Price	Availability
1 mg	$228	In Stock
5 mg	$579	In Stock
10 mg	$829	In Stock
25 mg	$1,260	In Stock
50 mg	$1,680	In Stock
100 mg	$2,280	In Stock
500 mg	$4,590	In Stock
1 mL x 10 mM (in DMSO)	$786	In Stock

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Product Introduction

Bioactivity

Description	CB-6644 is a selective inhibitor of the RUVBL1/2 complex and blocks the ATPase activity of RUVBL1/2 (IC50: 15 nM).
In vitro	CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (EC50: 41 to 785 nM).
In vivo	CB-6644 (150 mg/kg, p.o., 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models) has antitumor activity in xenograft tumor models. The tumor growth inhibitions (TGIs) are 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.

Chemical Properties

Molecular Weight	573.06
Formula	C29H34ClFN4O5
Cas No.	2316817-88-4

Storage & Solubility Information

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Solubility Information	DMSO: 1mg/ml

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Keywords

CB6644CB-6644InhibitorCB 6644inhibit