Powder: -20°C for 3 years
In solvent: -80°C for 2 years
CB2R/FAAH modulator-1, a cannabinoid type 2 receptor (CB2R) agonist, is also a fatty acid amide hydrolase (FAAH) inhibitor (IC50=4 μM) that reduces the production of pro-inflammatory and anti-inflammatory cytokines and is commonly used in inflammation studies. The Kis for CB2R and CB1R are 14.8 nM and 241.3 nM, respectively.
Description | CB2R/FAAH modulator-1, a cannabinoid type 2 receptor (CB2R) agonist, is also a fatty acid amide hydrolase (FAAH) inhibitor (IC50=4 μM) that reduces the production of pro-inflammatory and anti-inflammatory cytokines and is commonly used in inflammation studies. The Kis for CB2R and CB1R are 14.8 nM and 241.3 nM, respectively. |
Targets&IC50 | FAAH:4 μM, CB2R:14.8 nM(Kis), CB1R:241.3 nM(Kis) |
In vitro | CB2R/FAAH modulator-1 (compound 13; 10 μM; 24 h) decreases the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β, and IL6 production in unstimulated monocytes and macrophages[1]. |
Molecular Weight | 361.48 |
Formula | C24H27NO2 |
CAS No. | 928892-60-8 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 11 mg/mL (30.43 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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CB2R/FAAH modulator-1 928892-60-8 GPCR/G Protein Metabolism Neuroscience Cannabinoid Receptor FAAH CB2R/FAAH modulator1 Inhibitor inhibitor inhibit