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CB2R/FAAH modulator-1

Catalog No. T67896 CAS 928892-60-8

CB2R/FAAH modulator-1, a cannabinoid type 2 receptor (CB2R) agonist, is also a fatty acid amide hydrolase (FAAH) inhibitor (IC50=4 μM) that reduces the production of pro-inflammatory and anti-inflammatory cytokines and is commonly used in inflammation studies. The Kis for CB2R and CB1R are 14.8 nM and 241.3 nM, respectively.

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CB2R/FAAH modulator-1, CAS 928892-60-8

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Purity: 98%

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Description	CB2R/FAAH modulator-1, a cannabinoid type 2 receptor (CB2R) agonist, is also a fatty acid amide hydrolase (FAAH) inhibitor (IC50=4 μM) that reduces the production of pro-inflammatory and anti-inflammatory cytokines and is commonly used in inflammation studies. The Kis for CB2R and CB1R are 14.8 nM and 241.3 nM, respectively.
Targets&IC50	FAAH:4 μM, CB2R:14.8 nM(Kis), CB1R:241.3 nM(Kis)
In vitro	CB2R/FAAH modulator-1 (compound 13; 10 μM; 24 h) decreases the pro-inflammatory cytokines TNFα, IFN-γ, IL-1β, and IL6 production in unstimulated monocytes and macrophages[1].

Molecular Weight	361.48
Formula	C24H27NO2
CAS No.	928892-60-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 11 mg/mL (30.43 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Francesca Intranuov, et al. Development of N-(1-Adamantyl)benzamides as Novel Anti-Inflammatory Multitarget Agents Acting as Dual Modulators of the Cannabinoid CB2 Receptor and Fatty Acid Amide Hydrolase. J Med Chem. 2023 Jan 12;66(1):235-250.

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Keywords

CB2R/FAAH modulator-1 928892-60-8 GPCR/G Protein Metabolism Neuroscience Cannabinoid Receptor FAAH CB2R/FAAH modulator1 Inhibitor inhibitor inhibit

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