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CCR4 antagonist 3-1

Catalog No. T60336Cas No. 1957-01-3

CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of radiolabeled [125I]TARC and macrophage-derived chemokine ( MDC) to CEM cell surface and inhibits TARC-mediated CEM cell migration in vitro with an IC50 value of 6.4 μM. CCR4 antagonist 3 inhibited the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to the CCR4 receptor on the surface of CEM cells and inhibited TARC-mediated migration of CEM cells in vitro with an IC50 value of 6.4 μM.

CCR4 antagonist 3-1

CCR4 antagonist 3-1

Purity: 99.53%
Catalog No. T60336Cas No. 1957-01-3
CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of radiolabeled [125I]TARC and macrophage-derived chemokine ( MDC) to CEM cell surface and inhibits TARC-mediated CEM cell migration in vitro with an IC50 value of 6.4 μM. CCR4 antagonist 3 inhibited the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to the CCR4 receptor on the surface of CEM cells and inhibited TARC-mediated migration of CEM cells in vitro with an IC50 value of 6.4 μM.
Pack SizePriceAvailabilityQuantity
1 mg$93In Stock
5 mg$228In Stock
10 mg$372In Stock
25 mg$728In Stock
50 mg$1,130In Stock
100 mg$1,530In Stock
500 mg$2,970In Stock
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Purity:99.53%
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Product Introduction

Bioactivity
Description
CCR4 antagonist 3-1 is a less active chemokine receptor 4 (CCR4) antagonist that inhibits [125I]TARC (thymus and activation-regulated chemokine) with an IC50 value of 1.7 μM. CCR4 antagonist 3-1 inhibits the binding of radiolabeled [125I]TARC and macrophage-derived chemokine ( MDC) to CEM cell surface and inhibits TARC-mediated CEM cell migration in vitro with an IC50 value of 6.4 μM. CCR4 antagonist 3 inhibited the binding of radiolabeled [125I]TARC and macrophage-derived chemokine (MDC) to the CCR4 receptor on the surface of CEM cells and inhibited TARC-mediated migration of CEM cells in vitro with an IC50 value of 6.4 μM.
In vivo
CCR4 antagonist 3-1 (compound 1) (0.5 mg/kg, i.v.; 2 mg/kg, p.o.; single dosage) exhibited a high clearance of 4.2 L/h/kg a short half-life of 0.4 h, and the oral bioavailability of 2%.[1]
Chemical Properties
Molecular Weight240.32
FormulaC14H12N2S
Cas No.1957-01-3
Storage & Solubility Information
Storagestore at low temperature | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (187.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.1611 mL20.8056 mL41.6112 mL208.0559 mL
5 mM0.8322 mL4.1611 mL8.3222 mL41.6112 mL
10 mM0.4161 mL2.0806 mL4.1611 mL20.8056 mL
20 mM0.2081 mL1.0403 mL2.0806 mL10.4028 mL
50 mM0.0832 mL0.4161 mL0.8322 mL4.1611 mL
100 mM0.0416 mL0.2081 mL0.4161 mL2.0806 mL

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