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CEP-28122

🥰Excellent
Catalog No. T2612Cas No. 1022958-60-6

CEP-28122 is a highly potent and selective, orally active ALK inhibitor.

CEP-28122

CEP-28122

🥰Excellent
Purity: 100%
Catalog No. T2612Cas No. 1022958-60-6
CEP-28122 is a highly potent and selective, orally active ALK inhibitor.
Pack SizePriceAvailabilityQuantity
1 mg$50In Stock
2 mg$75In Stock
5 mg$135In Stock
10 mg$219In Stock
25 mg$395In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
CEP-28122 is a highly potent and selective, orally active ALK inhibitor.
Targets&IC50
ALK:1.9 ± 0.5 nM
Kinase Assay
Flashplate assay for identification and evaluation of Aurora inhibitors: On this assay 384-well Basic Flashplate? as solid assay platform is used. The plates are coated overnight at 4 °C with dithiothreitol (DTT) at 100 μg/mL in PBS buffer and used after being washed twice with PBS. 5 μL of CCT137690 in 2% DMSO is added to each well followed by 15 μL master mix of kinase buffer (50 mM Tris pH 7.5, 10 mM NaCl, 2.5 mM MgCl2, 1 mM myelin basic protein (MBP), 20 μM ATP, and 0.025 μCi/μL 33P-ATP). Finally, 250 ng per well of Aurora-A enzyme is added. The plate is shaken for approximately 2 min on a flat-bed plate shaker and incubated for 2 hours at room temperature. The reaction is stopped by washing the plate twice on a 16-pin wash with 10 mM sodium pyrophosphate. The plate is then read on a TopCount-NXTTM. For the determination of the inhibitory activity against Aurora-B or Aurora-C, the same conditions are followed in the assay using Aurora-B or Aurora-C enzymes.
Chemical Properties
Molecular Weight539.07
FormulaC28H35ClN6O3
Cas No.1022958-60-6
SmilesN([C@@H]1[C@@]2(C[C@]([C@@H]1C(N)=O)(C=C2)[H])[H])C3=NC(NC=4C(OC)=C5C(=CC4)CC[C@@H](CC5)N6CCOCC6)=NC=C3Cl
Relative Density.1.357 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 10 mM
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.8550 mL9.2752 mL18.5505 mL92.7523 mL
5 mM0.3710 mL1.8550 mL3.7101 mL18.5505 mL
10 mM0.1855 mL0.9275 mL1.8550 mL9.2752 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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