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Cerevisterol

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Catalog No. TMA0984Cas No. 516-37-0

Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells. Cerevisterol acts as a natural agent for treating inflammatory diseases by targeting an MAPK, NF-κB, AP-1, and Nrf2-mediated HO-1 signaling cascade.

Cerevisterol

Cerevisterol

🥰Excellent
Catalog No. TMA0984Cas No. 516-37-0
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells. Cerevisterol acts as a natural agent for treating inflammatory diseases by targeting an MAPK, NF-κB, AP-1, and Nrf2-mediated HO-1 signaling cascade.
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Product Introduction

Bioactivity
Description
Cerevisterol is a cytotoxic steroid, can inhibit the activity of DNA polymerase alpha. It can stimulate NGF-mediated neurite outgrowth on PC12 cells.
In vitro
Cerevisterol suppresses the LPS-induced production of NO and PGE2, which is a plausible mechanism for this effect is by reducing the expression of iNOS and COX-2. Cerevisterol also decreases the expression of pro-inflammatory cytokines, such as TNF-α, IL-6, and IL-1β. Cerevisterol halted the nuclear translocation of NF-κB by blocking the phosphorylation of inhibitory protein κBα (IκBα) and suppressing NF-κB transactivation. The mitogen-activated protein kinases (MAPK) signaling pathways are also suppressed. Cerevisterol treatment also inhibited the transactivation of AP-1 and the phosphorylation of c-Fos. Furthermore, Cerevisterol could induce the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) by down-regulating Kelch-like ECH-associated protein 1 (Keap-1) and up-regulating hemeoxygenases-1 (HO-1) expression.
Chemical Properties
Molecular Weight430.66
FormulaC28H46O3
Cas No.516-37-0
SmilesCC(C)[C@@H](C)/C=C/[C@@H](C)[C@@H](CC1)[C@@](C)(CC[C@@H]2[C@@](C)(CC[C@@H](C3)O)[C@@]33O)[C@@H]1C2=C[C@H]3O
Relative Density.1.08 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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