Shopping Cart
- Remove All
Your shopping cart is currently empty
Cetrelimab
🥰Excellent
Catalog No. T76945Cas No. 2050478-92-5
Alias JNJ63723283, JNJ3283, JNJ 63723283, JNJ 3283
Cetrelimab (JNJ 63723283) is a humanized anti-PD-1 monoclonal antibody that dose-dependently increases T cell-mediated cytokine production and stimulates cytokine expression. It is used in multiple myeloma and bladder cancer research.
Cetrelimab
Cetrelimab
🥰Excellent
Catalog No. T76945Alias JNJ63723283, JNJ3283, JNJ 63723283, JNJ 3283Cas No. 2050478-92-5
Cetrelimab (JNJ 63723283) is a humanized anti-PD-1 monoclonal antibody that dose-dependently increases T cell-mediated cytokine production and stimulates cytokine expression. It is used in multiple myeloma and bladder cancer research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $197 | In Stock | |
| 5 mg | $516 | In Stock | |
| 10 mg | $828 | In Stock | |
| 25 mg | $1,230 | In Stock | |
| 50 mg | $1,650 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Cetrelimab"
Acetylcysteine
Cited
N-Acetyl-L-cysteine, N-Acetylcysteine, N-Acetyl Cysteine, NAC, LNAC
T0875616-91-1
Acetylcysteine (NAC) is an N-acetyl derivative of cysteine, a ROS inhibitor and mucolytic agent. Acetylcysteine induces apoptosis, can be used to reduce mucus thickness, and has anti-influenza viral activity.
- $33
Size
QTY
CitedGlucosamine Cited
D-Glucosamine, Chitosamine
T04293416-24-8
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
- $50
Size
QTY
CitedSodium Thiocyanate
T8033540-72-7
Sodium Thiocyanate, one of the main sources of the thiocyanate anion, is used as a precursor for the synthesis of pharmaceuticals and other specialty chemicals.
- $29
Size
QTY
Apremilast
CC-10004
T2923608141-41-9
Apremilast (CC-10004) (CC-10004) is a potent and orally active PDE4 (IC50=74 nM) with anti-inflammation activities.
- $43
Size
QTY
Lenalidomide Cited
CC-5013
T1642191732-72-6
Lenalidomide (CC-5013) is an immunomodulator with oral activity. Lenalidomide is a ligand for the ubiquitin E3 ligase cereblon (CRBN), which selectively ubiquitinates and degrades two lymphoid transcription factors, IKZF1 and IKZF3, via the CRBN-CRL4 ubiquitin ligase, and is commonly used in the synthesis of PROTAC products.
- $36
Size
QTY
CitedDisulfiram Cited
Tetraethylthiuram disulfide, TETD, NSC 190940
T005497-77-8
Disulfiram (TETD) is an inhibitor of the acetaldehyde dehydrogenase ALDH, inhibiting hALDH1 and hALDH2 (IC50=0.15/1.45 μM) with specificity. Disulfiram is acutely sensitized to alcohol and also inhibits GSDMD pore formation.
- $50
Size
QTY
CitedFisetin Cited
T2879528-48-3
Fisetin belongs to a group of natural flavonols with a variety of biological activities, including anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects.
- $41
Size
QTY
CitedBalsalazide disodium dihydrate
T4615150399-21-6
Balsalazide sodium hydrate (Balsalazide disodium) is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.Balsalazide sodium hydrate is a new 5-aminosalicylic acid (5-ASA) containing prodrug. High dose Balsalazide sodium hydrate(3.0 g twice daily) was superior in maintaining remission in patients with ulcerative colitis compared with a low dose (1.5 g twice daily) or a standard dose of mesalazine (0.5 g three times daily). All three treatments were safe and well tolerated [1]. Balsalazide sodium hydrate is approved for the treatment of mild-to-moderate active UC. It is efficacious for the induction of remission in mild to moderate UC and has a favorable safety profile, with the added advantages of greater efficacy of remission induction and rapidity of onset [2].
- $39
Size
QTY
Thalidomide Cited
Thalomid, Sedoval
T021350-35-1
Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
- $50
Size
QTY
CitedLinalool
Phantol, Linalol, (±)-Linalool
T2S226478-70-6
1. Linalool (Linalol), a natural compound of the essential oils, has been shown to have antinociceptive, antimicrobial, and anti-inflammatory properties. 2. Linalool was protected against LPS/GalN-induced liver injury through induction of antioxidant defense via Nrf2 activating and reduction inflammatory response via NF-κB inhibition. 3. Linalool biosynthesis and accumulation might be involved in plant defense against bacterial and fungal pathogens and be associated with field resistance to citrus canker. 4. Linalool significantly increased the expression of antioxidant enzymes regulated by Nrf-2 and diminished lung tissue levels of several pro-inflammatory cytokines, including tumor necrosis factor α (TNF-α) and interleukin (IL)-6.
- $29
Size
QTY
Acefylline
Theophyllineacetic acid, Theophylline-7-acetic acid, Carboxymethyltheophylline, acetyloxytheophylline
T2205652-37-9
Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help offset its stimulant effects
- $33
Size
QTY
Apilimod
STA 5326
T2018541550-19-0
Apilimod (STA 5326) inhibits the production of IL-12 and IL-23 and reduces dendritic cell infiltration in psoriasis.
- $43
Size
QTY
Select Batch
Concentration:2.32 mg/mL
Purity:>95%
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Cetrelimab (JNJ 63723283) is a humanized anti-PD-1 monoclonal antibody that dose-dependently increases T cell-mediated cytokine production and stimulates cytokine expression. It is used in multiple myeloma and bladder cancer research. |
| Targets&IC50 | PD-L1:111.7 ng/mL, PD-L2:138.6 ng/mL |
| In vitro | Cetrelimab targets a human IgG4 κmonoclonal antibody to PD-1. Cetrelimab blocks the interaction of PD-1 with PD-L1 and PD-L2 (IC50 of 111.7 ng/mL and 138.6 ng/mL, respectively). The EC50 value of cetrelimab was 0.4138 μg/mL (HEK-293 cells), and the Kd of binding PD-1 was 1.72 nM (HEK293 cells). [1] |
| In vivo | Cetrelimab (10 mg/kg, 21 days) reduced mean MC38 tumor volume in PD-1 knockin mice (hPD-1KI). In a PDX lung mouse model, cetrelimab (10 mg/kg every 5 days for 6 cycles) increased the number of peripheral T cells and reduced the average tumor volume. [1] |
| Alias | JNJ63723283, JNJ3283, JNJ 63723283, JNJ 3283 |
| Cas No. | 2050478-92-5 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Cetrelimab | purchase Cetrelimab | Cetrelimab cost | order Cetrelimab | Cetrelimab in vivo | Cetrelimab in vitro
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.