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Clausine E

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Catalog No. TN6779Cas No. 182261-83-2

Clausine E is an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. The binding of Clausine E to FTO was driven by positive entropy and negative enthalpy changes.

Clausine E

Clausine E

🥰Excellent
Purity: 98.77%
Catalog No. TN6779Cas No. 182261-83-2
Clausine E is an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. The binding of Clausine E to FTO was driven by positive entropy and negative enthalpy changes.
Pack SizePriceAvailabilityQuantity
1 mg145 €In Stock
5 mg361 €In Stock
10 mg536 €In Stock
25 mg845 €In Stock
50 mg1.168 €In Stock
1 mL x 10 mM (in DMSO)372 €In Stock
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Purity:98.77%
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Product Introduction

Bioactivity
Description
Clausine E is an inhibitor of fat mass and obesity-associated protein (FTO) demethylase activity. The binding of Clausine E to FTO was driven by positive entropy and negative enthalpy changes.
Chemical Properties
Molecular Weight241.24
FormulaC14H11NO3
Cas No.182261-83-2
SmilesOC1=C2C(C=3C(N2)=CC=CC3)=CC(C(OC)=O)=C1
Relative Density.1.400 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/ml (227.99 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.1452 mL20.7262 mL41.4525 mL207.2625 mL
5 mM0.8290 mL4.1452 mL8.2905 mL41.4525 mL
10 mM0.4145 mL2.0726 mL4.1452 mL20.7262 mL
20 mM0.2073 mL1.0363 mL2.0726 mL10.3631 mL
50 mM0.0829 mL0.4145 mL0.8290 mL4.1452 mL
100 mM0.0415 mL0.2073 mL0.4145 mL2.0726 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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