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Clozapine N-oxide dihydrochloride

Catalog No. T72112Cas No. 2250025-93-3

Clozapine N-oxide dihydrochloride, a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs), crosses the blood-brain barrier and activates DREADD receptors hM3Dq and hM4Di.

Clozapine N-oxide dihydrochloride

Clozapine N-oxide dihydrochloride

Purity: 98.11%
Catalog No. T72112Cas No. 2250025-93-3
Clozapine N-oxide dihydrochloride, a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs), crosses the blood-brain barrier and activates DREADD receptors hM3Dq and hM4Di.
Pack SizePriceAvailabilityQuantity
5 mg$46In Stock
10 mg$77In Stock
25 mg$127In Stock
50 mg$187In Stock
100 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$51In Stock
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Purity:98.11%
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Product Introduction

Bioactivity
Description
Clozapine N-oxide dihydrochloride, a derivative of Clozapine and an agonist of human muscarinic design receptors (DREADDs), crosses the blood-brain barrier and activates DREADD receptors hM3Dq and hM4Di.
Chemical Properties
Molecular Weight452.2
FormulaC18H22Cl4N4O
Cas No.2250025-93-3
Storage & Solubility Information
Storagestore under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 50 mg/mL (110.57 mM), Sonication is recommended.
DMSO: 200 mg/mL (481.07 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM2.2114 mL11.0571 mL22.1141 mL110.5705 mL
5 mM0.4423 mL2.2114 mL4.4228 mL22.1141 mL
10 mM0.2211 mL1.1057 mL2.2114 mL11.0571 mL
20 mM0.1106 mL0.5529 mL1.1057 mL5.5285 mL
50 mM0.0442 mL0.2211 mL0.4423 mL2.2114 mL
100 mM0.0221 mL0.1106 mL0.2211 mL1.1057 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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