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Combretastatin A-1

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Catalog No. T36848Cas No. 109971-63-3
Alias Combretastatin A1

Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated inactivation of AKT to inhibit the Wnt/β-catenin pathway, and can be used to study hepatocellular carcinoma.

Combretastatin A-1

Combretastatin A-1

😃Good
Purity: 97.49%
Catalog No. T36848Alias Combretastatin A1Cas No. 109971-63-3
Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated inactivation of AKT to inhibit the Wnt/β-catenin pathway, and can be used to study hepatocellular carcinoma.
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1 mg33 €In Stock
1 mL x 10 mM (in DMSO)84 €5 days
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Purity:97.49%
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Product Introduction

Bioactivity
Description
Combretastatin A-1 is a potent microtubule inhibitor with anti-tumour and anti-vascular activity, acting through microtubule protein depolymerisation-mediated inactivation of AKT to inhibit the Wnt/β-catenin pathway, and can be used to study hepatocellular carcinoma.
Targets&IC50
CT-26:1075 nM, HepG2 cells:9.2 nM, Hepa 1-6:32.9 nM, Huh7:728.2 nM, LM-3:33.8 nM, A375:61 nM, MCF-7 cells:46.0 nM, Smmc 7721 cells:12.8 nM, Bel-7402:38.4 nM, MDA-MB-231 cells:17.6 nM, BGC-803:12.2 nM, NCI-1975:256.3 nM
In vitro
Combretastatin A-1 (CA1P) induces apoptosis of TAMs in vitro through the same mechanism observed in HepG2 cells, and it eliminates TAMs in the tumor microenvironment (TME) in vivo. Combretastatin A-1 (1-10 nM; 24 hours) induces AKT inactivation and removal of GSK-3β inhibition by microtubule depolymerization, leading to HepG2 cell apoptosis [2]. Combretastatin A-1 (1-50 nM; 6 hours) reduces the mitochondrial membrane potential (MMP) of HepG2 cells and induces the accumulation of ROS in a dose-dependent manner [3].
In vivo
In the HepG2 subcutaneous xenograft model, Combretastatin A-1 (1-4 mg/kg; i.v. every other day for 4 weeks) significantly reduces the tumor volume [3].
In the orthotopic hepatocellular carcinoma mouse model, Combretastatin A-1 (2 mg/kg; every other day for 21 days) demonstrates enhanced apoptosis [3].
AliasCombretastatin A1
Chemical Properties
Molecular Weight332.35
FormulaC18H20O6
Cas No.109971-63-3
SmilesCOc1ccc(\C=C/c2cc(OC)c(OC)c(OC)c2)c(O)c1O
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (240.71 mM), Sonication is recommended.
DMF: 5 mg/mL
Ethanol: 3 mg/mL
DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0089 mL15.0444 mL30.0888 mL150.4438 mL
5 mM0.6018 mL3.0089 mL6.0178 mL30.0888 mL
10 mM0.3009 mL1.5044 mL3.0089 mL15.0444 mL
20 mM0.1504 mL0.7522 mL1.5044 mL7.5222 mL
50 mM0.0602 mL0.3009 mL0.6018 mL3.0089 mL
100 mM0.0301 mL0.1504 mL0.3009 mL1.5044 mL

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