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Coniine hydrochloride

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COA HNMR

Coniine hydrochloride

Catalog No. TN3695Cas No. 15991-59-0

Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system.

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Pack Size	Price	Availability
1 mg	$45	In Stock
5 mg	$106	In Stock
10 mg	$172	In Stock
25 mg	$347	In Stock
50 mg	$553	In Stock
100 mg	$868	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock

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Product Introduction

Bioactivity

Description	Coniine hydrochloride, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system.
In vitro	Reduction of γ-coniceine to coniine is facilitated by NADPH-dependent γ-coniceine reductase.?Although coniine is notorious for its toxicity, there is no consensus on its ecological roles, especially in the carnivorous pitcher plants where it occurs.?Lately there has been renewed interest in coniine's medical uses particularly for pain relief without an addictive side effect.

Chemical Properties

Molecular Weight	163.7
Formula	C8H18ClN
Cas No.	15991-59-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 27.5 mg/ml (167.99 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.1087 mL	30.5437 mL	61.0874 mL	305.4368 mL
5 mM	1.2217 mL	6.1087 mL	12.2175 mL	61.0874 mL
10 mM	0.6109 mL	3.0544 mL	6.1087 mL	30.5437 mL
20 mM	0.3054 mL	1.5272 mL	3.0544 mL	15.2718 mL
50 mM	0.1222 mL	0.6109 mL	1.2217 mL	6.1087 mL
100 mM	0.0611 mL	0.3054 mL	0.6109 mL	3.0544 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Coniine HydrochlorideConiine hydrochloride