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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | Inquiry | Backorder | |
50 mg | Inquiry | Backorder |
Description | COX-2/15-LOX-IN-3 (compound 5k) is a dual inhibitor of COX-2 and 15-LOX with inhibitory concentrations (IC50) of 0.075 μM and 1.97 μM, respectively. This compound effectively suppresses LPS-induced production of pro-inflammatory cytokines (IL-6, ROS, and NO), exhibiting targeted anti-inflammatory effects [1]. |
In vitro | Compound 5k (COX-2/15-LOX-IN-3) suppresses LPS-induced IL-6, ROS, and NO production in the RAW 264.7 macrophage cell line with respective IC50 values of 63.03 μM, 167.91 μM, and 39.31 μM [1]. |
Molecular Weight | 465.54 |
Formula | C25H24FN3O3S |
Cas No. |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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