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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $41 | In Stock | |
10 mg | $57 | In Stock | |
25 mg | $135 | In Stock | |
50 mg | $232 | In Stock | |
100 mg | $348 | In Stock |
Description | Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications. |
In vitro | Cucurbit[8]uril (0~20 μM; 48 hours; CHO-K1 cells) marginally reduces cell viability to 86%[2]. It selectively induces heterodimerization of MV-eYFP with Np-eCFP and high energy transfer between the proteins, observed only with all three supramolecular components forming the ternary complex. Cucurbit[8]uril inhibits unspecific protein assembly induced by methylviologen and enables the formation of selective protein heterodimers with more hydrophobic proteins. It prevents MV-induced unspecific dimerization with hydrophobic protein surfaces[1]. |
In vivo | Cucurbit[8]uril exhibits minimal toxicity when administered either intravenously or orally in mice, as demonstrated by in vivo studies[2]. |
Molecular Weight | 1329.1 |
Formula | C48H48N32O16 |
Cas No. | 259886-51-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: < 1 mg/mL |
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