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D-Kynurenine

D-Kynurenine
D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.
Catalog No. T10938Cas No. 13441-51-5
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Purity:97.08%
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D-Kynurenine

Catalog No. T10938Cas No. 13441-51-5

D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.
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Pack SizePriceAvailabilityQuantity
25 mg$29In Stock
50 mg$48In Stock
100 mg$79In Stock
200 mg$125In Stock
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Product Introduction

Bioactivity
Description
D-Kynurenine (ZINC901103) is a metabolite of D-tryptophan and an agonist of GPR109B. D-Kynurenine activates AhR and promotes the conversion of the epithelium to mesenchyme. D-Kynurenine serves as a substrate in the fluorescence analysis of D-amino acid oxidase.
In vitro
D-Kynurenine (10-100 µM) induces DER-enhancement and positively regulates the transfer of 95D cells, which is attenuated after siRNAAhr treatment in VIM and E-cadherin. D-Kynurenine (10 and 40 µM) significantly increases VIM expression and induces CYP1A1 upregulation. D-Kynurenine (10 µM) significantly attenuates the level of E-cadherin[4].
Alias(R)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid, ZINC901103
Chemical Properties
Molecular Weight208.21
FormulaC10H12N2O3
Cas No.13441-51-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 5 mg/mL (24.01 mM), Sonication and heating to 60℃ are recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM4.8028 mL24.0142 mL48.0284 mL240.1422 mL
5 mM0.9606 mL4.8028 mL9.6057 mL48.0284 mL
10 mM0.4803 mL2.4014 mL4.8028 mL24.0142 mL
20 mM0.2401 mL1.2007 mL2.4014 mL12.0071 mL

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