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Desglymidodrine
🥰Excellent
Catalog No. T31388LCas No. 3600-87-1
Alias ST1059, ST 1059
Desglymidodrine (ST 1059) is a selective α1-adrenoceptor agonist and an active metabolite of Midodrine. It is a vasoconstrictor that can be used for cardiovascular research and neurocardiogenic syncope.
Desglymidodrine
🥰Excellent
Catalog No. T31388LAlias ST1059, ST 1059Cas No. 3600-87-1
Desglymidodrine (ST 1059) is a selective α1-adrenoceptor agonist and an active metabolite of Midodrine. It is a vasoconstrictor that can be used for cardiovascular research and neurocardiogenic syncope.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 5 mg | $77 | In Stock | |
| 10 mg | $123 | In Stock | |
| 25 mg | $222 | In Stock | |
| 50 mg | $313 | In Stock | |
| 100 mg | $467 | In Stock | |
| 200 mg | $669 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Desglymidodrine (ST 1059) is a selective α1-adrenoceptor agonist and an active metabolite of Midodrine. It is a vasoconstrictor that can be used for cardiovascular research and neurocardiogenic syncope. |
| Targets&IC50 | α2A adrenergic receptor (human):5.83 (pKi), α1B adrenergic receptor (rat):5.16 (pKi), α1D adrenergic receptor (rat):5.78 (pKi), α1A adrenergic receptor (rat):5.89 (pKi) |
| In vitro | Desglymidodrine affects venoconstriction over a concentration range of 1-1000 μM, with a pD2 value of 4.64 (-log mol/L) in isolated canine femoral veins and 4.48 (-log mol/L) in isolated human saphenous veins. [1] Desglymidodrine binds to α1A, α1B, and α1D adrenergic receptors in rats and α2A adrenergic receptors in humans, corresponding to pKi values of 5.89, 5.16, 5.78, and 5.83, respectively. [2] |
| Alias | ST1059, ST 1059 |
| Molecular Weight | 197.23 |
| Formula | C10H15NO3 |
| Cas No. | 3600-87-1 |
| Smiles | OC(C1=CC(OC)=CC=C1OC)CN |
| Relative Density. | 1.145 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40.00 mg/mL (202.81 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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