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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2]. |
In vitro | Methylation analysis reveals a [3H]DHAC LD 10 exposure leads to 25.06% DNA hypomethylation in L1210/0 cells and 46.32% in L1210/dCK(-) deoxycytidine kinase mutant cells relative to controls [2]. Furthermore, dihydro-5-azacytidine (DHAC) vies with cytidine triphosphate for RNA integration, culminating in ribosomal breakdown and impaired protein synthesis [1]. |
In vivo | In a murine model bearing L1210/0-induced tumors, administration of an LD 10 of Dihydro-5-azacytidine (DHAC; 1500 mg/kg) results in a peak plasma concentration of 317 μM. The compound is biexponentially eliminated, with a first-phase half-life (t 1/2 α) of 1.03 hours and a second-phase half-life (t 1/2 β) of 5 hours [2]. |
Alias | DHAC acetate, NSC 264880 acetate |
Molecular Weight | 306.27 |
Formula | C10H18N4O7 |
Cas No. | 2470972-18-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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