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Dihydro-5-azacytidine acetate
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Catalog No. T78565Cas No. 2470972-18-8
Alias NSC 264880 acetate, DHAC acetate
Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2].
Dihydro-5-azacytidine acetate
😃Good
Catalog No. T78565Alias NSC 264880 acetate, DHAC acetateCas No. 2470972-18-8
Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, integrates into DNA to inhibit DNA methylation and exhibits antitumor activity [1] [2]. |
| In vitro | Methylation analysis reveals a [3H]DHAC LD 10 exposure leads to 25.06% DNA hypomethylation in L1210/0 cells and 46.32% in L1210/dCK(-) deoxycytidine kinase mutant cells relative to controls [2]. Furthermore, dihydro-5-azacytidine (DHAC) vies with cytidine triphosphate for RNA integration, culminating in ribosomal breakdown and impaired protein synthesis [1]. |
| In vivo | In a murine model bearing L1210/0-induced tumors, administration of an LD 10 of Dihydro-5-azacytidine (DHAC; 1500 mg/kg) results in a peak plasma concentration of 317 μM. The compound is biexponentially eliminated, with a first-phase half-life (t 1/2 α) of 1.03 hours and a second-phase half-life (t 1/2 β) of 5 hours [2]. |
| Alias | NSC 264880 acetate, DHAC acetate |
| Molecular Weight | 306.27 |
| Formula | C10H18N4O7 |
| Cas No. | 2470972-18-8 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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