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Dihydro-5-azacytidine (DHAC) is an active nucleoside analog with anti-leukemic activity that inhibits cell growth and induces DNA hypomethylation.Dihydro-5-azacytidine is used in the study of leukemia and tumors.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | Backorder |
Description | Dihydro-5-azacytidine (DHAC) is an active nucleoside analog with anti-leukemic activity that inhibits cell growth and induces DNA hypomethylation.Dihydro-5-azacytidine is used in the study of leukemia and tumors. |
In vitro | As a nucleoside analogue, Dihydro-5-azacytidine (DHAC) competes with cytidine triphosphate for incorporation into RNA, resulting in ribosomal degradation and defective protein synthesis [1]. |
In vivo | In tumor-bearing mice (injected with L1210/0 cells), receiving an LD 10 dose of Dihydro-5-azacytidine (DHAC; 1500 mg/kg) results in a peak plasma concentration of 317 μM, with biexponential elimination characterized by a half-life (t 1/2) of 1.03 hours (α phase) and 5 hours (β phase)[2]. |
Alias | NSC264880, DHAC, 5,6-Dihydro-5-azacytidine |
Molecular Weight | 246.22 |
Formula | C8H14N4O5 |
Cas No. | 62488-57-7 |
Smiles | O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=C(N)NC2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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