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Estrogen receptor modulator 10
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Catalog No. T82439Cas No. 2991504-90-4
Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1/G0 phase, making it applicable in cancer research [1].
Estrogen receptor modulator 10
😃Good
Catalog No. T82439Cas No. 2991504-90-4
Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1/G0 phase, making it applicable in cancer research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Compound G-5b, an estrogen receptor modulator 10, functions as an estrogen receptor (ER) antagonist (IC50=6.7 nM) and degrader (DC50=0.4 nM). It has the capability to induce apoptosis and block cells at the G1/G0 phase, making it applicable in cancer research [1]. |
| In vitro | The estrogen receptor modulator 10, at concentrations of 20-100 nM applied for 2-48 hours, significantly suppresses the activity of the estrogen receptor (ER) in T47D cells in a dose-dependent manner. In MCF-7 cells, it elicits a delayed reduction in the degradation level of cellular ER compared to T47D cells [1]. |
| In vivo | Estrogen receptor modulator 10 (30 mg/kg, intramuscular (i.m.) injection, single dose) exhibited favorable pharmacokinetic properties in female Sprague-Dawley rats [1]. |
| Molecular Weight | 728.71 |
| Formula | C32H37F9N4O3S |
| Cas No. | 2991504-90-4 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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