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ET receptor antagonist 3
ET receptor antagonist 3
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ET receptor antagonist 3
Catalog No. T79575
"ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH) research. This compound demonstrates efficacy in mitigating monocrotaline-induced PAH in a rat model [1]."
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | "ET receptor antagonist 3 (compound 17d) is an orally active ET receptor antagonist with an IC50 of 0.26 nM, utilized for pulmonary arterial hypertension (PAH) research. This compound demonstrates efficacy in mitigating monocrotaline-induced PAH in a rat model [1]." |
| In vivo | Administered orally at 150 mg/kg/day and 300 mg/kg/day starting 48 hours post-MCT treatment for 21 to 26 days, ET receptor antagonist 3 (compound 17d) significantly reduced mean pulmonary arterial pressure (mPAP) in MCT-exposed rats, decreased levels of HIF1α, ANP, and TNNI3, exhibited antioxidant activity, and inhibited lipid peroxidation [1]. |
| Molecular Weight | 548.61 |
| Formula | C27H28N6O5S |
| Cas No. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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