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Etanercept
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Catalog No. T37445Cas No. 185243-69-0
Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.[1]
Etanercept
🥰Excellent
Purity: 98%
Catalog No. T37445Cas No. 185243-69-0
Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.[1]
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $328 | In Stock | |
| 5 mg | $663 | In Stock | |
| 10 mg | $995 | In Stock | |
| 25 mg | $1,470 | In Stock | |
| 50 mg | $1,990 | In Stock | |
| 100 mg | $2,680 | In Stock |
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Concentration:47.7 mg/mL
Purity:98%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Etanercept is a fusion protein consisting of the soluble portion of the p75-tumor necrosis factor receptor (TNFR) and the Fc fragment of human IgG1 and is commonly used to treat patients with rheumatoid arthritis.[1] |
| In vitro | METHODS: CHLA-255 cells were co-cultured with human monocytes and treated with etanercept (10 μg/mL). TNF-α levels in the co-culture supernatant were measured by TNF-α ELISA; supernatant IL-6 levels were measured by ELISA. RESULTS Treatment of NB-monocyte co-cultures with etanercept blocked almost all sTNF-α and IL-6 production. Etanercept effectively disrupted the pro-tumorigenic mTNF-α/TNFR2 signaling axis between NB cells and monocytes, preventing NF-κB activation in both cell types. This reduced monocyte pro-tumorigenic cytokine production, ultimately leading to increased apoptosis and decreased proliferation of NB cells in vitro. [1] |
| In vivo | METHODS: Tumor-bearing mice were injected intraperitoneally with etanercept (5 mg/kg) twice a week. Tumor growth was measured by bioluminescence imaging. RESULTS Etanercept treatment reduced tumor growth by 30% (p<0.05). [1] METHODS: Etanercept (10 mg/kg/3 days, subcutaneous injection) or saline was administered in AIA rats for 3 weeks at the first signs of arthritis. Body weight and arthritis scores were monitored daily. RESULTS Etanercept significantly reduced arthritis scores (P < 0.001). [2] |
| Cas No. | 185243-69-0 |
Storage & Solubility Information
| Storage | store at low temperature | store at -80°C | Shipping with blue ice. |
| Solubility Information | DMSO: Soluble |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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