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Eudebeiolide B
Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is applicable in the study of osteoclast-related diseases [1].
Catalog No. T79932Cas No. 1934299-51-0
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Eudebeiolide B
Catalog No. T79932Alias Plebeiolide DCas No. 1934299-51-0
Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is applicable in the study of osteoclast-related diseases [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
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| 5 mg | Inquiry | Backorder | |
| 50 mg | Inquiry | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Eudebeiolide B, isolated from Salvia plebeia R. Br., impedes osteoclastogenesis by modulating RANKL-induced NF-κB, c-Fos, and calcium signaling pathways, and is applicable in the study of osteoclast-related diseases [1]. |
| In vitro | Eudebeiolide B (1-30 μΜ, 1 hour) inhibits RANKL-induced cellular differentiation in murine bone marrow-derived macrophages, suppressing the expression of osteoclastogenesis-related marker genes and RANKL-mediated cell signaling [1]. |
| In vivo | Eudebeiolide B (5 or 10 mg/kg, administered orally once a day for 6 weeks) prevented bone loss in an ovariectomized (OVX) mouse model caused by bilateral ovariectomy (OVX) [1]. |
| Alias | Plebeiolide D |
| Molecular Weight | 262.3 |
| Formula | C15H18O4 |
| Cas No. | 1934299-51-0 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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