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FDW028
🥰Excellent
Catalog No. T77809Cas No. 2768426-49-7
Alias FDW 028
FDW028 is a selective and potent fucosyltransferase 8 (FUT8) inhibitor with anti-tumor activity that drives B7-H3 lysosomal degradation via defucosylation and CMA pathways. FUT8 can be used to study metastatic colorectal cancer (mCRC).
FDW028
🥰Excellent
Catalog No. T77809Alias FDW 028Cas No. 2768426-49-7
FDW028 is a selective and potent fucosyltransferase 8 (FUT8) inhibitor with anti-tumor activity that drives B7-H3 lysosomal degradation via defucosylation and CMA pathways. FUT8 can be used to study metastatic colorectal cancer (mCRC).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 5 mg | $153 | In Stock | |
| 10 mg | $247 | In Stock | |
| 25 mg | $517 | In Stock | |
| 50 mg | $828 | In Stock | |
| 100 mg | $1,320 | In Stock | |
| 500 mg | $2,650 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $169 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | FDW028 is a selective and potent fucosyltransferase 8 (FUT8) inhibitor with anti-tumor activity that drives B7-H3 lysosomal degradation via defucosylation and CMA pathways. FUT8 can be used to study metastatic colorectal cancer (mCRC). |
| Targets&IC50 | HCT-8 cells:23.78 μM, SW480 cells:5.95 μM |
| In vitro | METHODS: FDW028 (0.316-316μM, 72 hours) was used to treat SW480 and HCT-8 cells, and cell viability was detected with or without FUT8 knockdown. RESULTS:FDW028 exhibited potent antitumor capabilities in terms of cell proliferation, with half-maximal inhibitory concentration (IC50) values ​​of 5.95 µM and 23.78 µM in SW480 and HCT-8 cells, respectively. [1] METHODS: SW480 and HCT-8 cells were treated with FDW028 (50 μM, 72 hours) for Transwell and wound healing assays. RESULTS:FDW028 significantly inhibited the migration of SW480 and HCT-8 cells. [1] |
| In vivo | METHODS: FDW028 (10, 20 mg/kg, intravenous injection, 4-6 weeks) was administered to athymic male SCID tumor xenograft mice to explore the effect of FDW028 on CRC growth. RESULTS:FDW028 exerted potent antitumor activity against CRC and significantly inhibited the growth of mouse tumors. [1] |
| Alias | FDW 028 |
| Molecular Weight | 388.47 |
| Formula | C22H24N6O |
| Cas No. | 2768426-49-7 |
| Smiles | OC1=CC(=NC2=NC(=NN21)NCC3=CC=C(C=C3)CC)CNCC=4C=CC=CC4 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL（205.94 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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