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Feniralstat

🥰Excellent
Catalog No. T63507Cas No. 2166320-76-7
Alias KVD-824, KVD824

Feniralstat (KVD-824) is a selective and highly efficient kallikrein inhibitor. It can be used for researching immune system diseases and cardiovascular diseases.

Feniralstat

Feniralstat

🥰Excellent
Purity: 99.52%
Catalog No. T63507Alias KVD-824, KVD824Cas No. 2166320-76-7
Feniralstat (KVD-824) is a selective and highly efficient kallikrein inhibitor. It can be used for researching immune system diseases and cardiovascular diseases.
Pack SizePriceAvailabilityQuantity
1 mg$198 In Stock
5 mg$519 In Stock
10 mg$743 In Stock
25 mg$1,520 In Stock
50 mg$1,980 In Stock
1 mL x 10 mM (in DMSO)$590 In Stock
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Purity:99.52%
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Product Introduction

Bioactivity
Description
Feniralstat (KVD-824) is a selective and highly efficient kallikrein inhibitor. It can be used for researching immune system diseases and cardiovascular diseases.
Targets&IC50
plasma kallikrein (pKal) (human):6.7 nM
In vitro
Feniralstat (Compound 30) is a pyrazole derivative that potently inhibits kallikrein with an IC50 of 6.7 nM for human plasma kallikrein (pKal).Feniralstat weakly inhibits human KLK1, human FXIa, and human Factor XIIa (all with IC50s above 40 μM). [1]
AliasKVD-824, KVD824
Chemical Properties
Molecular Weight509.51
FormulaC26H25F2N5O4
Cas No.2166320-76-7
SmilesO=C1C=CC(F)=CN1CC2=CC=C(C=C2)CN3N=C(C(=C3)C(=O)NCC4=NC=CC(OC)=C4F)COC
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80.00 mg/mL (157.01 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9627 mL9.8134 mL19.6267 mL98.1335 mL
5 mM0.3925 mL1.9627 mL3.9253 mL19.6267 mL
10 mM0.1963 mL0.9813 mL1.9627 mL9.8134 mL
20 mM0.0981 mL0.4907 mL0.9813 mL4.9067 mL
50 mM0.0393 mL0.1963 mL0.3925 mL1.9627 mL
100 mM0.0196 mL0.0981 mL0.1963 mL0.9813 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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