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FPA-124
🥰Excellent
Catalog No. T11317Cas No. 902779-59-3
Alias FPA124, Akt Inhibitor XI
FPA-124 is a cell-permeable copper complex that acts as a selective Akt (protein kinase B) inhibitor interacting with the homology (PH) and kinase structural domains of Akt to induce apoptosis. It has the advantage of being highly potent and exhibits dose-dependent growth inhibition in a variety of cancer cell lines.
FPA-124
🥰Excellent
Purity: 95.04%
Catalog No. T11317Alias FPA124, Akt Inhibitor XICas No. 902779-59-3
FPA-124 is a cell-permeable copper complex that acts as a selective Akt (protein kinase B) inhibitor interacting with the homology (PH) and kinase structural domains of Akt to induce apoptosis. It has the advantage of being highly potent and exhibits dose-dependent growth inhibition in a variety of cancer cell lines.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $86 | In Stock | |
| 5 mg | $190 | In Stock | |
| 10 mg | $282 | In Stock | |
| 25 mg | $480 | In Stock | |
| 50 mg | $720 | In Stock | |
| 100 mg | $1,080 | In Stock |
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Purity:95.04%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | FPA-124 is a cell-permeable copper complex that acts as a selective Akt (protein kinase B) inhibitor interacting with the homology (PH) and kinase structural domains of Akt to induce apoptosis. It has the advantage of being highly potent and exhibits dose-dependent growth inhibition in a variety of cancer cell lines. |
| In vitro | FPA-124 can inhibit the growth of BT20, PC-3, COLO 357 and BxPC-3 cancer cells in a concentration-dependent manner with IC50 values of 7, 10, 34 and 55 μM, respectively. [1] |
| In vivo | FPA-124 treatment inhibits PKB (Akt protein) activity and leads to inactivation of NF-κB in a mature orthotopic pancreatic tumor model mouse model bearing COLO 357 cells. [1] |
| Alias | FPA124, Akt Inhibitor XI |
| Molecular Weight | 381.73 |
| Formula | C11H9Cl2CuN3O2S |
| Cas No. | 902779-59-3 |
| Smiles | O=C1C=2C(OC=C1C=[N]3[Cu+2]([Cl-])([Cl-])[S]=C(N)N3)=CC=CC2 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||
| Solubility Information | DMSO: 2 mg/mL (5.24 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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