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FPA-124
FPA-124, a cell-permeable copper complex and selective Akt inhibitor with an IC50 of 0.1 μM, engages the pleckstrin homology (PH) and kinase domains of Akt, inducing apoptosis.
Catalog No. T11317Cas No. 902779-59-3
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FPA-124
Catalog No. T11317Cas No. 902779-59-3
FPA-124, a cell-permeable copper complex and selective Akt inhibitor with an IC50 of 0.1 μM, engages the pleckstrin homology (PH) and kinase domains of Akt, inducing apoptosis.
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Bioactivity
Chemical Properties
| Description | FPA-124, a cell-permeable copper complex and selective Akt inhibitor with an IC50 of 0.1 μM, engages the pleckstrin homology (PH) and kinase domains of Akt, inducing apoptosis. |
| In vitro | FPA-124 demonstrates dose-dependent growth inhibition in various cancer cell lines with IC50 values of 7 μM in BT20, 10 μM in PC-3, 34 μM in COLO 357, and 55 μM in BxPC-3. |
| In vivo | FPA-124 demonstrates inhibitory effects on PKB (Akt protein) and leads to the inactivation of NF-κB within a validated orthotopic pancreatic tumor model utilizing COLO 357 cells. |
| Molecular Weight | 381.73 |
| Formula | C11H9Cl2CuN3O2S |
| Cas No. | 902779-59-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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