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FPA-124

Name: FPA-124
Brand: TargetMol
SKU: T11317
Rating: 4.5 (1 reviews)

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Catalog No. T11317Cas No. 902779-59-3

FPA-124, a cell-permeable copper complex and selective Akt inhibitor with an IC50 of 0.1 μM, engages the pleckstrin homology (PH) and kinase domains of Akt, inducing apoptosis.

FPA-124

🥰Excellent

Catalog No. T11317Cas No. 902779-59-3

FPA-124, a cell-permeable copper complex and selective Akt inhibitor with an IC50 of 0.1 μM, engages the pleckstrin homology (PH) and kinase domains of Akt, inducing apoptosis.

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Product Introduction

Bioactivity

Description	FPA-124, a cell-permeable copper complex and selective Akt inhibitor with an IC50 of 0.1 μM, engages the pleckstrin homology (PH) and kinase domains of Akt, inducing apoptosis.
In vitro	FPA-124 demonstrates dose-dependent growth inhibition in various cancer cell lines with IC50 values of 7 μM in BT20, 10 μM in PC-3, 34 μM in COLO 357, and 55 μM in BxPC-3.
In vivo	FPA-124 demonstrates inhibitory effects on PKB (Akt protein) and leads to the inactivation of NF-κB within a validated orthotopic pancreatic tumor model utilizing COLO 357 cells.

Chemical Properties

Molecular Weight	381.73
Formula	C₁₁H₉Cl₂CuN₃O₂S
Cas No.	902779-59-3
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

FPA-124FPA124FPA 124