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FPI-1523 sodium, a derivative of avibactam, is a potent β-lactamase inhibitor with Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. It inhibited PBP2 with an IC50 of 3.2 μM and has a high level of antibacterial and considerable antimicrobial activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $67 | In Stock | |
5 mg | $163 | In Stock | |
10 mg | $263 | In Stock | |
25 mg | $538 | In Stock | |
50 mg | $768 | In Stock |
Description | FPI-1523 sodium, a derivative of avibactam, is a potent β-lactamase inhibitor with Kd values of 4 nM and 34 nM for CTX-M-15 and OXA-48, respectively. It inhibited PBP2 with an IC50 of 3.2 μM and has a high level of antibacterial and considerable antimicrobial activity. |
In vitro | FPI-1523 sodium effectively inhibits both E. coli K12 and its PBP2, displaying minimum inhibitory concentrations (MIC) and half-maximal inhibitory concentrations (IC50) of 4 μg/mL and 0.4 μg/mL, respectively. Additionally, it demonstrates potent inhibition against E. coli BW25113 pGDP-2 transformants, irrespective of the presence of an empty vector or the expression of various β-lactamases, achieving low MIC values (1-2 μM).[1] |
Molecular Weight | 344.27 |
Formula | C9H13N4NaO7S |
Cas No. | 1452459-52-7 |
Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (130.33 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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