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Ganoderic acid C1
😃Good
Catalog No. TN1660Cas No. 95311-97-0
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 protease.
Ganoderic acid C1
😃Good
Catalog No. TN1660Cas No. 95311-97-0
Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 protease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $198 | 35 days | |
| 5 mg | $695 | 35 days | |
| 10 mg | $1,280 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ganoderic acid C1 has anti-inflammatory activity, has potential for treating TNF-α± mediated inflammation in asthma and other inflammatory diseases. Ganoderic acid C1 has anti-tumor-promoting activity. It is moderately active inhibitors against HIV-1 prot |
| In vitro | Ganoderic acid C1 was isolated from G. lucidum. Stimulated RAW 264.7 macrophages were treated with Ganoderic acid C1. Human PBMCs and colonic biopsies were obtained from children with CD and cultured with or without Ganoderic acid C1. TNF-α± and other proinflammatory cytokine levels were measured in the culture supernatant. NF-κB signaling was investigated in PBMCs and colonic mucosa treated with Ganoderic acid C1 by In-Cell Western and Western blot analysis. GAC1 decreased TNF-α± production by macrophages and PBMCs from CD subjects. Ganoderic acid C1 significantly decreased TNF-α±, IFN-γ, and IL-17A production by inflamed colonic biopsies from CD subjects. These effects were due to the downregulation of the NF-κB signaling pathway[1]. |
| Molecular Weight | 514.65 |
| Formula | C30H42O7 |
| Cas No. | 95311-97-0 |
| Smiles | [H][C@@]1(CC(=O)[C@@]2(C)C3=C(C(=O)C[C@]12C)[C@@]1(C)CCC(=O)C(C)(C)[C@]1([H])C[C@@H]3O)[C@H](C)CC(=O)C[C@@H](C)C(O)=O |
| Relative Density. | 1.22 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 48 mg/mL (93.26 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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