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GK187

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Catalog No. T37221Cas No. 1071001-50-7
Alias GK 187

GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.

GK187

GK187

🥰Excellent
Catalog No. T37221Alias GK 187Cas No. 1071001-50-7
GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.
Pack SizePriceAvailabilityQuantity
1 mg$156In Stock
5 mg$383In Stock
10 mg$568In Stock
25 mg$916In Stock
50 mg$1,190In Stock
100 mg$1,910In Stock
200 mg$2,570In Stock
1 mL x 10 mM (in DMSO)$393In Stock
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Product Introduction

Bioactivity
Description
GK187 is a selective and potent Group VIA calcium-independent phospholipase A2 (GVIA iPLA2) inhibitor, used in the study of neurological disorders.
Targets&IC50
A2 GVIA iPLA2:0.0001 (XI50)
In vitro
GK187 is a selective VIA group calcium-independent phospholipase (A2 GVIA iPLA2) inhibitor with an XI (50) value of 0.0001 and no significant inhibition of GIVA cPLA2 or GV sPLA2. [1]
AliasGK 187
Chemical Properties
Molecular Weight310.26
FormulaC14H15F5O2
Cas No.1071001-50-7
SmilesO=C(CCCCC1=CC=C(OC)C=C1)C(F)(F)C(F)(F)F
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 5 mg/mL (16.12 mM), Sonication is recommended.
DMSO: 80 mg/mL (257.85 mM), Sonication is recommended.
Ethanol:PBS (pH 7.2) (1:2): < 1 mg/mL (Insoluble.)
DMF: 5 mg/mL (16.12 mM), Sonication is recommended.
Solution Preparation Table
Ethanol/DMF/DMSO
1mg5mg10mg50mg
1 mM3.2231 mL16.1155 mL32.2310 mL161.1552 mL
5 mM0.6446 mL3.2231 mL6.4462 mL32.2310 mL
10 mM0.3223 mL1.6116 mL3.2231 mL16.1155 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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