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Glucosylsphingosine

Name: Glucosylsphingosine
Brand: TargetMol
SKU: T78493
Rating: 4.5 (1 reviews)

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Catalog No. T78493Cas No. 52050-17-6

Alias Lyso-Gb1, Glucosyl-C18-sphingosine, Glucopsychosine, 1-β-D-Glucosylsphingosine

Glucosylsphingosine (Lyso-Gb1) is a naturally occurring glycosyl ceramide, a metabolite of GBA (acid β-glucosidase), involved in cellular recognition, signaling, and intercellular interactions.Glucopsychosine accumulates in certain neurodegenerative diseases (e.g., Gaucher disease), disrupts lysosomal function through activation of mammalian target of rapamycin complex 1 (mTORC1), and is a noncompetitive inhibitor of glucocerebrosidase.

Glucosylsphingosine

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Catalog No. T78493Alias Lyso-Gb1, Glucosyl-C18-sphingosine, Glucopsychosine, 1-β-D-GlucosylsphingosineCas No. 52050-17-6

Pack Size	Price	Availability	Quantity
1 mg	$280	35 days
5 mg	$830	35 days

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Product Introduction

Bioactivity

Description	Glucosylsphingosine (Lyso-Gb1) is a naturally occurring glycosyl ceramide, a metabolite of GBA (acid β-glucosidase), involved in cellular recognition, signaling, and intercellular interactions.Glucopsychosine accumulates in certain neurodegenerative diseases (e.g., Gaucher disease), disrupts lysosomal function through activation of mammalian target of rapamycin complex 1 (mTORC1), and is a noncompetitive inhibitor of glucocerebrosidase.
In vitro	Methods: MCF7 cells were treated with glucosylsphingosine (20-45 μM, 48 hours), and cell death was determined by PI and Hoechst-33342 staining. Results: Glucosylsphingosine killed MCF7 cells independently of apoptosis, ferroptosis, and necroptosis, and induced cell death in a dose-dependent manner, with an LC50 of 33 μM.[4]
In vivo	Methods: Adult male C57BL/6JRj mice were treated with glucosylsphingosine (10 mg/kg, subcutaneous injection, daily, for 12 consecutive weeks) and the inflammatory changes in the mice were observed. Results: Glucosylsphingosine accumulated in peripheral tissues and induced hematological symptoms in mice, such as decreased hemoglobin and hematocrit, increased spleen weight, and mild inflammatory tissue reactions, indicating that it induced visceral inflammatory reactions in mice. [6]
Alias	Lyso-Gb1, Glucosyl-C18-sphingosine, Glucopsychosine, 1-β-D-Glucosylsphingosine

Chemical Properties

Molecular Weight	461.63
Formula	C₂₄H₄₇NO₇
Cas No.	52050-17-6
Smiles	O(C[C@@H]([C@@H](/C=C/CCCCCCCCCCCCC)O)N)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 100 mg/mL (216.62 mM), Sonication is recommended.

DMSO: 80 mg/mL (173.3 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.1662 mL	10.8312 mL	21.6624 mL	108.3119 mL
5 mM	0.4332 mL	2.1662 mL	4.3325 mL	21.6624 mL
10 mM	0.2166 mL	1.0831 mL	2.1662 mL	10.8312 mL
20 mM	0.1083 mL	0.5416 mL	1.0831 mL	5.4156 mL
50 mM	0.0433 mL	0.2166 mL	0.4332 mL	2.1662 mL
100 mM	0.0217 mL	0.1083 mL	0.2166 mL	1.0831 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc