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Gly3-VC-PAB-MMAE

Name: Gly3-VC-PAB-MMAE
Brand: TargetMol
SKU: T40308
Rating: 4.5 (1 reviews)

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Catalog No. T40308Cas No. 2684216-48-4

Gly3-VC-PAB-MMAE A compound consisting of the ADC linker Gly3-VC-PAB and the microtubule inhibitor MMAE, which can be used to synthesize antibody-coupled reactive molecules.

Gly3-VC-PAB-MMAE

😃Good

Catalog No. T40308Cas No. 2684216-48-4

Gly3-VC-PAB-MMAE A compound consisting of the ADC linker Gly3-VC-PAB and the microtubule inhibitor MMAE, which can be used to synthesize antibody-coupled reactive molecules.

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Product Introduction

Bioactivity

Description	Gly3-VC-PAB-MMAE A compound consisting of the ADC linker Gly3-VC-PAB and the microtubule inhibitor MMAE, which can be used to synthesize antibody-coupled reactive molecules.
In vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Chemical Properties

Molecular Weight	1294.58
Formula	C₆₄H₁₀₃N₁₃O₁₅
Cas No.	2684216-48-4
Relative Density.	1.205 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50.00 mg/mL (38.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.7725 mL	3.8623 mL	7.7245 mL	38.6226 mL
5 mM	0.1545 mL	0.7725 mL	1.5449 mL	7.7245 mL
10 mM	0.0772 mL	0.3862 mL	0.7725 mL	3.8623 mL
20 mM	0.0386 mL	0.1931 mL	0.3862 mL	1.9311 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc