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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $249 | In Stock |
Description | GNE-371 is a probe for selective human transcription initiation factor TFIID subunit 1 and transcription initiation factor TFIID subunit 1-like second bromodomain. |
In vitro | GNE-371 (Compound 27) binds to TAF1(2) with an IC50 of 10 nM, while maintaining excellent selectivity over other bromodomain-family members. GNE-371 also exhibits activity in a cellular TAF1(2) target-engagement assay (IC50 = 38 nM) and shows synergistic antiproliferative effects with the BET inhibitor JQ1[1]. |
Molecular Weight | 431.49 |
Formula | C24H25N5O3 |
Cas No. | 1926986-36-8 |
Storage | store under nitrogen,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (69.53 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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