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GNE-371
🥰Excellent
Catalog No. T15401Cas No. 1926986-36-8
GNE-371 is a probe for selective human transcription initiation factor TFIID subunit 1 and transcription initiation factor TFIID subunit 1-like second bromodomain.
GNE-371
🥰Excellent
Purity: 98%
Catalog No. T15401Cas No. 1926986-36-8
GNE-371 is a probe for selective human transcription initiation factor TFIID subunit 1 and transcription initiation factor TFIID subunit 1-like second bromodomain.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $299 | In Stock |
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Purity:98%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | GNE-371 is a probe for selective human transcription initiation factor TFIID subunit 1 and transcription initiation factor TFIID subunit 1-like second bromodomain. |
| Targets&IC50 | TAF12:10 nM |
| In vitro | GNE-371 (Compound 27) binds to TAF1(2) with an IC50 of 10 nM, while maintaining excellent selectivity over other bromodomain-family members. GNE-371 also exhibits activity in a cellular TAF1(2) target-engagement assay (IC50 = 38 nM) and shows synergistic antiproliferative effects with the BET inhibitor JQ1[1]. |
| Molecular Weight | 431.49 |
| Formula | C24H25N5O3 |
| Cas No. | 1926986-36-8 |
| Smiles | Cn1cnc2c(cc(cc12)C(=O)N1CCOCC1)-c1cn(CCC=C)c(=O)c2[nH]ccc12 |
| Relative Density. | 1.36 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (69.53 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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