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GNE-8505
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Catalog No. T11440Cas No. 1620573-48-9
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
GNE-8505
😃Good
Catalog No. T11440Cas No. 1620573-48-9
GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $920 | 8-10 weeks | |
| 50 mg | $1,180 | 8-10 weeks | |
| 100 mg | $1,790 | 8-10 weeks |
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Questions
QCan Tween-80 be used instead of Tween-20?
ATween-20 is not recommended. Tween-80 has better tolerance and has been used as a tool to assess the behavioral effects of experimental drugs and toxins without significant side effects.
Reference: Castro CA, Hogan JB, Benson KA, Shehata CW, Landauer MR. Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620. Pharmacol Biochem Behav. 1995 Apr;50(4):521-6.
QIf the product does not dissolve even when it is below the maximum solubility stated in the instructions, what should I do?
AIt is recommended to utilize some auxiliary dissolution methods, such as heating to 45°C or using sonication to accelerate dissolution.
QWhat should I do if the IC50 obtained for cell killing are significantly different from that presented on the your website?
AThe IC50 you obtain refers to the cell proliferation inhibition assay (half maximal inhibitory concentration), which is different in meaning from the IC50 on our website. The IC50 often refers to the inhibition rate of the target without cell experiments, which is generally determined through kinase or protein purification experiments, and is commonly reported in nanomolar concentrations. However, the IC50 obtained from cell proliferation inhibition assays refers to the half-maximal lethality of the cells, which involves cellular metabolism and penetration, so the concentration is usually higher.
Furthermore, the effect of the same compound on different cell models varies. It is recommended to try increasing the incubation volume and extending the incubation time.
QCan inhibitors be used for cell experiments?
AYes, our inhibitors can be used for cell/in vitro experiments. However, some compounds may not have literature supporting their use in cell experiments. In such cases, we cannot guarantee efficacy.
QI need a total of 500 mg of the product for animal experiments, but it won't be used up all at once. How should I dissolve it?
ADetermining the amount based on solution clarity.1. If the prepared solution is clear, it can be prepared in a larger amount for one-time use and stored at 4°C. It is recommended to prepare the solution once a week, as prolonged storage may lead to loss of efficacy. 2. If the prepared solution is a suspension, it is recommended to prepare and use immediately each time.
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CitedContact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK). |
| Molecular Weight | 419.44 |
| Formula | C21H24F3N5O |
| Cas No. | 1620573-48-9 |
| Relative Density. | 1.69 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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