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Treosulfan

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Purity:99.26%

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COA HPLC HNMR

Treosulfan

Catalog No. T17159Cas No. 299-75-2

Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.

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Pack Size	Price	Availability
2 mg	$34	In Stock
5 mg	$55	In Stock
10 mg	$89	In Stock
25 mg	$178	In Stock
50 mg	$322	In Stock
100 mg	$572	In Stock
500 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$61	In Stock

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Product Introduction

Bioactivity

Description	Treosulfan (Treosulphan) is a bifunctional alkylating agent. It also has activity in ovarian cancer and other solid tumor types.
In vitro	Treosulfan inhibits several cancer cell lines, such as Panc-1, Miapaca-2 and Capan-2 cells (IC50s: 3.6 μg/mL, 1.8 μg/mL and 2.1 μg/mL respectively). It also shows nearly 100% cytotoxicity on these cell lines at 100 μg/mL. Treosulfan (1, 2.5, 5 μg/ml) combined with 5-FU (0.1, 0.25, 0.5 μg/ml) has antagonistic effect on Panc-1 cells at intermediate and high concentrations, and on Miapaca-2 cells at all doses. Treosulfan (0.1-100 μg/mL) in combination with LY 188011 exhibits enhanced activity against cancer cells. Treosulfan (800 μg/mL) dramatically decreases erythrocyte forward scatter, increases the percentage of annexin-V-binding cells, [Ca2+]i, and ROS [1][2].
In vivo	Treosulfan (1.5 g/kg/day) induces only interleukin-2 production in spleen cells for a short time. Treosulfan (1.5 g/kg/day) causes a rapid myeloablation, depletes the splenic B and T cells in mice [3].
Alias	NSC 39069, Treosulphan

Chemical Properties

Molecular Weight	278.3
Formula	C6H14O8S2
Cas No.	299-75-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (359.32 mM)

H2O: 50 mg/mL (179.66 mM)

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	3.5932 mL	17.9662 mL	35.9324 mL	179.6622 mL
5 mM	0.7186 mL	3.5932 mL	7.1865 mL	35.9324 mL
10 mM	0.3593 mL	1.7966 mL	3.5932 mL	17.9662 mL
20 mM	0.1797 mL	0.8983 mL	1.7966 mL	8.9831 mL
50 mM	0.0719 mL	0.3593 mL	0.7186 mL	3.5932 mL
100 mM	0.0359 mL	0.1797 mL	0.3593 mL	1.7966 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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