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Lomeguatrib
Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
Catalog No. T2495Cas No. 192441-08-0
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Lomeguatrib
Catalog No. T2495Cas No. 192441-08-0
Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) .
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $43 | In Stock | |
| 10 mg | $54 | In Stock | |
| 25 mg | $95 | In Stock | |
| 50 mg | $162 | In Stock | |
| 100 mg | $297 | In Stock | |
| 500 mg | $743 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $48 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lomeguatrib (PaTrin-2), a modified guanine base, inhibits the activity of DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT) . |
| Targets&IC50 | MGMT:5 nM |
| In vitro | In the A375M human melanoma xenograft model, intraperitoneal injection of Lomeguatrib (20 mg/kg) treatment was found to inhibit ATase activity. |
| In vivo | In Raji cells, Lomeguatrib inhibits ATase activity with an IC50 value of 10 nM, while in MCF-7 cells, it effectively inhibits MGMT with an IC50 of 6 nM. |
| Alias | PaTrin-2 |
| Molecular Weight | 326.17 |
| Formula | C10H8BrN5OS |
| Cas No. | 192441-08-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 55 mg/mL (168.62 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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