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GPP78
😃Good
Catalog No. T15412Cas No. 1202580-59-3
Alias CAY10618
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effects.
GPP78
😃Good
Catalog No. T15412Alias CAY10618Cas No. 1202580-59-3
GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effects.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 500 μg | 46 € | 35 days | |
| 1 mg | 88 € | 35 days | |
| 5 mg | 346 € | 35 days | |
| 10 mg | 610 € | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effect |
| In vitro | GPP78 appears truly cytotoxic in melanoma cell lines, while in the others it is mainly cytostatic. GPP78 inhibits the growth of most cell lines tested, with nanomolar potency (GI50) in cell lines derived from leukemia, lung, CNS, colon, melanoma, ovarian, renal, and prostate cancers. GPP78 (10 nM; 24-40 hours; SH-SY5Y cells) treatment with cells, punctate staining of LC3-II, and the formation of autophagolysosomes are observable. LC3-II is membrane-bound and is present in autophagosomes [1]. |
| In vivo | GPP78 (i.p.; daily; 10 mg/kg; 1 hour or 6 hours after SCI; for 19 days; male adult CD1 mice) treatment decreases the severity of spinal cord trauma in SCI mice [2]. |
| Alias | CAY10618 |
| Molecular Weight | 439.55 |
| Formula | C27H29N5O |
| Cas No. | 1202580-59-3 |
| Relative Density. | 1.15 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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