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GSK2292767
😃Good
Catalog No. T6850Cas No. 1254036-66-2
GSK2292767 is a potent and selective inhibitor of PI3Kδ.
GSK2292767
😃Good
Catalog No. T6850Cas No. 1254036-66-2
GSK2292767 is a potent and selective inhibitor of PI3Kδ.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $110 | 35 days | |
| 5 mg | $494 | 35 days | |
| 10 mg | $889 | 35 days | |
| 25 mg | $1,990 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GSK2292767 is a potent and selective inhibitor of PI3Kδ. |
| In vitro | BI-847325 shows growth-inhibitory effects on BRAF-mutant and vemurafenib-resistant melanoma cells with IC50 ranging from 0.3 nM to 2 μM, and prevents colony formation in six BRAF-mutant melanoma cell lines. BI-847325 also induces apoptosis by reducing Mcl-1 expression. [1] |
| In vivo | GSK2292767 is highly selective for PI3Kδ over the closely related isoforms and is active in a disease relevant brown Norway rat acute OVA model of Th2-driven lung inflammation[1]. |
| Molecular Weight | 512.58 |
| Formula | C24H28N6O5S |
| Cas No. | 1254036-66-2 |
| Relative Density. | 1.360 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 93 mg/mL (181.4 mM) Ethanol: <1 mg/mL H2O: <1 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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