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GSK2292767 FA
GSK2292767 FA is a potent and selective inhibitor of PI3Kδ (pIC50 : 10.1).GSK2292767 FA is more than 500-fold more selective than other PI3K isoforms.GSK2292767 FA can be used in the study of respiratory diseases.
Catalog No. T6850L
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Purity:99.21%
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GSK2292767 FA
Catalog No. T6850LAlias GSK2292767 FA(1254036-66-2 Free base)
GSK2292767 FA is a potent and selective inhibitor of PI3Kδ (pIC50 : 10.1).GSK2292767 FA is more than 500-fold more selective than other PI3K isoforms.GSK2292767 FA can be used in the study of respiratory diseases.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $157 | In Stock | |
| 5 mg | $390 | In Stock | |
| 10 mg | $578 | Backorder | |
| 25 mg | $928 | Backorder | |
| 50 mg | $1,260 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GSK2292767 FA is a potent and selective inhibitor of PI3Kδ (pIC50 : 10.1).GSK2292767 FA is more than 500-fold more selective than other PI3K isoforms.GSK2292767 FA can be used in the study of respiratory diseases. |
| In vivo | GSK2292767 in a brown Norwegian rat acute OVA model of Th2 driven pulmonary inflammation in rats 35 μg/kg of ED50 protects eosinophil recruitment.[1] In rat PK studies, GSK2292767 showed a high clearance rate (50 mL/min/kg) and low oral bioavailability (F<2%) in vivo.[1] |
| Alias | GSK2292767 FA(1254036-66-2 Free base) |
| Molecular Weight | 558.61 |
| Formula | C25H30N6O7S |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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