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GSK_WRN4

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Catalog No. T200332Cas No. 2923008-66-4

GSK_WRN4 is a WRN helicase inhibitor with anticancer activity. It induces DNA double-strand breaks and inhibits MSI tumor cell growth, making it useful in cancer research.

GSK_WRN4

GSK_WRN4

🥰Excellent
Purity: 100%
Catalog No. T200332Cas No. 2923008-66-4
GSK_WRN4 is a WRN helicase inhibitor with anticancer activity. It induces DNA double-strand breaks and inhibits MSI tumor cell growth, making it useful in cancer research.
Pack SizePriceAvailabilityQuantity
1 mg$953 In Stock
5 mg$1,780 In Stock
10 mg$2,380 In Stock
25 mg$3,570 In Stock
50 mg$4,790 In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
GSK_WRN4 is a WRN helicase inhibitor with anticancer activity. It induces DNA double-strand breaks and inhibits MSI tumor cell growth, making it useful in cancer research.
Targets&IC50
WRN helicase:7.6 (pIC50)
In vitro
GSK_WRN4 significantly inhibited WRN helicase activity with pIC50 value of 7.6.
GSK_WRN4 (0.1-20 μM, 1.5-144h) treated SW48 cells in a time - and dose-dependent manner. [1]
In vivo
In a xenografted mouse model of colorectal cancer cell lines, dose-dependent tumor growth inhibition was observed by oral administration of GSK_WRN4 (30, 100, 300 mpk), and tumor growth was completely inhibited at the highest dose supported by favorable pharmacokinetics.
Morphological and pathological analysis of explants showed that GSK_WRN4 treatment resulted in a decrease in SW48 tumor cell density, accompanied by increased stromal and extracellular matrix deposition. [1]
Chemical Properties
Molecular Weight336.41
FormulaC16H20N2O4S
Cas No.2923008-66-4
SmilesO=C1NC(=CC=C1C(N[C@@H]2C=CS(=O)(=O)C2)=O)C3CCCCC3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (237.81 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9726 mL14.8628 mL29.7256 mL148.6282 mL
5 mM0.5945 mL2.9726 mL5.9451 mL29.7256 mL
10 mM0.2973 mL1.4863 mL2.9726 mL14.8628 mL
20 mM0.1486 mL0.7431 mL1.4863 mL7.4314 mL
50 mM0.0595 mL0.2973 mL0.5945 mL2.9726 mL
100 mM0.0297 mL0.1486 mL0.2973 mL1.4863 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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