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GSK_WRN4 is a WRN helicase inhibitor with anticancer activity. It induces DNA double-strand breaks and inhibits MSI tumor cell growth, making it useful in cancer research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $953 | In Stock | |
5 mg | $1,780 | In Stock | |
10 mg | $2,380 | In Stock | |
25 mg | $3,570 | In Stock | |
50 mg | $4,790 | In Stock |
Description | GSK_WRN4 is a WRN helicase inhibitor with anticancer activity. It induces DNA double-strand breaks and inhibits MSI tumor cell growth, making it useful in cancer research. |
Targets&IC50 | WRN helicase:7.6 (pIC50) |
In vitro | GSK_WRN4 significantly inhibited WRN helicase activity with pIC50 value of 7.6. GSK_WRN4 (0.1-20 μM, 1.5-144h) treated SW48 cells in a time - and dose-dependent manner. [1] |
In vivo | In a xenografted mouse model of colorectal cancer cell lines, dose-dependent tumor growth inhibition was observed by oral administration of GSK_WRN4 (30, 100, 300 mpk), and tumor growth was completely inhibited at the highest dose supported by favorable pharmacokinetics. Morphological and pathological analysis of explants showed that GSK_WRN4 treatment resulted in a decrease in SW48 tumor cell density, accompanied by increased stromal and extracellular matrix deposition. [1] |
Molecular Weight | 336.41 |
Formula | C16H20N2O4S |
Cas No. | 2923008-66-4 |
Smiles | O=C1NC(=CC=C1C(N[C@@H]2C=CS(=O)(=O)C2)=O)C3CCCCC3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (237.81 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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