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Heptamidine dimethanesulfonate

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Purity:98.24%

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COA HPLC HNMR

Heptamidine dimethanesulfonate

Catalog No. T11553Cas No. 161374-55-6

Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) serves as a potent inhibitor related to Pentamidine, targeting the calcium-binding protein S100B with a dissociation constant (Kd) of 6.9 µM. It demonstrates specificity by preferentially killing melanoma cells overexpressing S100B compared to cells lacking this protein. Additionally, Heptamidine is employed as a valuable research tool in the study of Myotonic dystrophy (DM).

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Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$179	In Stock
10 mg	$289	In Stock
25 mg	$496	In Stock
50 mg	$745	In Stock
100 mg	$1,090	In Stock
1 mL x 10 mM (in DMSO)	$223	In Stock

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Product Introduction

Bioactivity

Description	Heptamidine dimethanesulfonate (SBi4211 dimethanesulfonate) serves as a potent inhibitor related to Pentamidine, targeting the calcium-binding protein S100B with a dissociation constant (Kd) of 6.9 µM. It demonstrates specificity by preferentially killing melanoma cells overexpressing S100B compared to cells lacking this protein. Additionally, Heptamidine is employed as a valuable research tool in the study of Myotonic dystrophy (DM).
In vitro	Heptamidine rescues the mis-splicing of minigene reporters in a HeLa cell DM1 model (EC50: 15 μM). Heptamidine (20 μM) does not decrease CUG levels significantly when compares to Propamidine and Pentamidine, and exhibits cytotoxic at concentrations above 17.5 μM in HeLa cells expressing 960 CUG repeats [2].
In vivo	Heptamidine (i.p.; 20 or 30 mg/kg; 7 days) causes a dose-dependent reduction of exon 7a inclusion in HSALR mice, returning to wild type levels (6±1%) when at 20 mg/kg dose, the myotonia is reduced from grade 3 to grade 1 (occasional myotonic discharge) or grade 0 at both 20 or 30 mg/kg [2].
Alias	SBi4211 dimethanesulfonate

Chemical Properties

Molecular Weight	560.68
Formula	C23H36N4O8S2
Cas No.	161374-55-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 70 mg/mL (124.85 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7835 mL	8.9177 mL	17.8355 mL	89.1774 mL
5 mM	0.3567 mL	1.7835 mL	3.5671 mL	17.8355 mL
10 mM	0.1784 mL	0.8918 mL	1.7835 mL	8.9177 mL
20 mM	0.0892 mL	0.4459 mL	0.8918 mL	4.4589 mL
50 mM	0.0357 mL	0.1784 mL	0.3567 mL	1.7835 mL
100 mM	0.0178 mL	0.0892 mL	0.1784 mL	0.8918 mL

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mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

HeptamidinedystrophyHeptamidine dimethanesulfonateSBi 4211MyotonicSBi4211inhibitCalcium-BindingcancermelanomaSBi-4211S100BHeLaInhibitorcell