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Ipsalazide
Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease.
Catalog No. T19379Cas No. 82101-17-5
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Purity:99.43%
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Ipsalazide
Catalog No. T19379Cas No. 82101-17-5
Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $700 | 6-8 weeks | |
| 5 mg | $1,800 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ipsalazide is a novel salicylazosulfapyridine analog for the treatment of inflammatory bowel disease. |
| In vitro | Ipsalazide is designed with the replacement of the sulfapyridine of sulfasalazine by carrier molecules, aiming to mitigate side effects. Sulfasalazine exerts beneficial effects in colitis by releasing 5-aminosalicylic acid in the colon, but its use can be limited by side effects[1]. |
| In vivo | Within 7 days of a single oral dose of ipsalazide (4 g/kg in mice or 2 g/kg in rats), no deaths or visible abnormalities occurred. At postmortem, no abnormalities were observed. The carrier molecule of ipsalazide (ABG) is readily absorbed, with nearly half of the dose appearing in the urine. However, approximately 40% of the ABG was not recovered, and it is possible that this has undergone further metabolism, resulting in the loss of the aromatic amine function, which is the basis for the colorimetric measurement of ABG[1]. |
| Molecular Weight | 387.25 |
| Formula | C16H11N3Na2O6 |
| Cas No. | 82101-17-5 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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