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ISO-1

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Purity:98.56%

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COA HPLC HNMR

ISO-1

Catalog No. T3680Cas No. 478336-92-4

ISO-1 (MIF Antagonist) is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.

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Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$64	In Stock
10 mg	$98	In Stock
25 mg	$183	In Stock
50 mg	$322	In Stock
100 mg	$513	In Stock
500 mg	$875	In Stock
1 g	$1,230	In Stock
1 mL x 10 mM (in DMSO)	$70	In Stock

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Product Introduction

Bioactivity

Description	ISO-1 (MIF Antagonist) is an inhibitor of the dopachrome tautomerase activity, blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages.
Alias	MIF Antagonist, ISO 1

Chemical Properties

Molecular Weight	235.24
Formula	C12H13NO4
Cas No.	478336-92-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (191.29 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.2510 mL	21.2549 mL	42.5098 mL	212.5489 mL
5 mM	0.8502 mL	4.2510 mL	8.5020 mL	42.5098 mL
10 mM	0.4251 mL	2.1255 mL	4.2510 mL	21.2549 mL
20 mM	0.2125 mL	1.0627 mL	2.1255 mL	10.6274 mL
50 mM	0.0850 mL	0.4251 mL	0.8502 mL	4.2510 mL
100 mM	0.0425 mL	0.2125 mL	0.4251 mL	2.1255 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorISO-1ISO1inhibit